Curcumin

Anti-cancer Activities

Bladder Cancer

1. Curcumin Promotes KLF5 Proteasome Degradation through Downregulating YAP/TAZ in Bladder Cancer Cells

2. Curcumin modulates micrRNA-203 mediated regulation of the Src-Akt axis in bladder cancer

Bone Cancer

1. Curcumin Induces Cell Cycle Arrest and Apoptosis in Human Osteosarcoma (HOS) Cells

2. Apoptotic effects of curcumin on human osteosarcomaU2OS cells

Brain Cancer

1. Investigating the therapeutic role and molecular biology of curcumin as a treatment for glioblastoma

2. Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells

Breast Cancer

Cervical Cancer

In Vitro

1. Curcumin induces G2/M arrest and triggers autophagy,ROS generation and cell senescence in cervical cancer cells (2020)

2. Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells (2019)

3. Curcumin inhibits cervical cancer cell proliferation, migration and invasion by suppressing the PI3K/AKT signaling pathway via the miR-29b/KDM2A axis (2019)

4. Lopinavir and Curcumin Directly Alters BAX/BCL2 andVEGF165b mRNA Levels to Suppress Human SquamousCervical Carcinoma Cell Growth (2018)

5. Curcumin causes DNA damage and affects associated proteinexpression in HeLa human cervical cancer cells (2016)

6. Combined ultrasound-curcumin treatment of human cervical cancer cells (2014)

7. Reversal of Resistance towards Cisplatin by Curcumin inCervical Cancer Cells (2014)

8. Curcumin Suppresses Human Papillomavirus Oncoproteins, Restores p53, Rb, and PTPN13Proteins and Inhibits Benzo[a]pyrene-Induced Upregulation of HPV E7 (2010)

9. Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells (2010)

10. The Chemopreventive Agent Curcumin Is a Potent Radiosensitizer of Human Cervical Tumor Cells via IncreasedReactive Oxygen Species Production and Overactivation of the Mitogen-Activated Protein Kinase Pathway (2008)

11. Effects of Curcumin on Invasion and Metastasis in the Human Cervical Cancer Cells Caski (2008)

12. Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells (2008)

13. Antitumor Action of Curcumin in Human Papillomavirus Associated Cells Involves Downregulation of Viral Oncogenes, Prevention of NFkB and AP-1 Translocation, and Modulation of Apoptosis (2005)

14. EFFECTS OF CURCUMIN ON PROLIFERATION AND APOPTOSIS OF HUMAN CERVICAL CARCINOMA HeLa CELLS IN VITRO (2003)

In Vivo

1. Effects of Notch Signaling Pathway in Cervical Cancer by Curcumin Mediated Photodynamic Therapy and Its Possible Mechanisms in Vitro and in Vivo (2018)

2. Effects of Curcumin on Vascular Endothelial Growth Factor Expression on Rattus norvegicus Cervical Cancer Xenograft Model (2018)

3. Effects of curcumin on growth of human cervical cancer xenograft in nude mice and underlying mechanism (2017)

4. Unique synergistic formulation of curcumin, epicatechin gallate and resveratrol, tricurin, suppresses HPV E6, eliminates HPV+ cancer cells, and inhibits tumor progression (2016)

5. Assessment of In vitro – In vivo Antimigratory and Anti-angiogenic Activity of Curcuma longa Linn. and Tinospora cordifolia Willd. Extracts in Cervical Cancer (2016)

6. Curcumin: A Potent Candidate to be Evaluated as a Chemosensitizer in Paclitaxel Chemotherapy Against Cervical Cancer (2014)

7. Antitumor and Antiangiogenic Activities of Curcumin in Cervical Cancer Xenografts in Nude Mice (2013)

8. A novel curcumin-based vaginal cream Vacurin selectively eliminates apposed human cervical cancer cells (2013)

9. Anti-Tumor Effect of Curcumin on Human Cervical Carcinoma HeLa Cells In Vitro and In Vivo (2007)

Clinical trials

1. Phase I dose-escalation trial of intravaginal curcumin in women for cervical dysplasia (2017)

2. Effect of curcumin in prevention of pre-invasive lesions of the cervix (2017)

3. Clearance of Cervical Human Papillomavirus Infection by Topical Application of Curcumin and Curcumin Containing Polyherbal Cream: A Phase II Randomized Controlled Study (2013)

Review

Basic research on curcumin in cervical cancer: Progress and perspectives (2023)

Cholangiocarcinoma

1. Curcumin‑loaded nanocomplexes alleviate the progression of fluke‑related cholangiocarcinoma in hamsters (2023)

2. Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma (2023)

3. Potentiation of TRAIL-Induced Apoptosis in TRAIL-Resistant Cholangiocarcinoma Cells by Curcumin through the Induction of DR5 Membrane Localization and Disruption of the Anti-Apoptotic Complex DR5/DDX3/GSK3β (2023)

4. Curcumin enhances chemotherapeutic effects and suppresses ANGPTL4 in anoikis-resistant cholangiocarcinoma cells (2020)

5. Discovering proteins for chemoprevention and chemotherapy by curcumin in liver fluke infection-induced bile duct cancer (2018)

6. Curcumin in Hepatobiliary Disease: Pharmacotherapeutic Properties and Emerging Potential Clinical Applications (2017)

7. Curcumin-mediated regulation of Notch1/hairy and enhancer of split-1/survivin: molecular targeting in cholangiocarcinoma (2015)

8. Anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of Thai medicinal plants in animal models (2012)

9. Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways (2011)

10. Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis (2011)

11. Redox modulation and human bile duct cancer inhibition by curcumin (2010)

Colorectal Cancer

In Vitro

1. Curcumin Sensitizes Silymarin to Exert Synergistic Anticancer Activity in Colon Cancer Cells

2. Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU

3. Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway

4. Curcumin mediates oxaliplatin acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway

5. Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer

6. Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures

7. Curcumin Modulates DNA Methylation in Colorectal Cancer Cells

8. Curcumin Enhances the Effect of Chemotherapy against Colorectal Cancer Cells by Inhibition of NF-kB and Src Protein Kinase Signaling Pathways

9. Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells

10. Curcumin Targets FOLFOX-surviving Colon Cancer Cells via Inhibition of EGFRs and IGF-1R

11. Curcumin Modulates the Radiosensitivity of Colorectal Cancer Cells by Suppressing Constitutive and Inducible NF-κB Activity

12. Curcumin Inhibits Proliferation of Colorectal Carcinoma by Modulating Akt/mTOR Signaling

13. Elimination of Colon Cancer Stem-Like Cells by the Combination of Curcumin and FLOFOX

In Vivo

1. Expanding the Therapeutic Utility of Curcumin: An Experimental Study on DMH-induced Colorectal Cancer

2. Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/b-Catenin Pathways via miR-130a

3. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelialto-mesenchymal transition in chemoresistant colorectal cancer

4. Curcumin Regulates Colon Cancer by Inhibiting P-Glycoprotein in In-situ Cancerous Colon Perfusion Rat Model

5. Possible therapeutic mechanisms of turmeric against colorectal cancer induced by N-methylnitrosourea in experimental models

6. Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo

7. Curcumin Enhances Dasatinib Induced Inhibition of Growth and Transformation of Colon Cancer Cells

8. Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to -Radiation by Targeting Nuclear Factor-B-Regulated Gene Products

Clinical trials

1. Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial

2. Phase IIA Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

3. Colorectal Cancer: Chemopreventive Role of Curcumin and Resveratrol

4. Anti-carcinogenic properties of curcumin on colorectal Cancer

5. Curcumin for chemoprevention of colon cancer

Lung Cancer

In Vitro

1. Curcumin Inhibits Growth of Human NCI-H292 Lung Squamous Cell Carcinoma Cells by Increasing FOXA2 Expression

2. Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway

3. Curcumin induced autophagy anticancer effects on human lung adenocarcinoma cell line A549

4. Curcumin and Lung Cancer: the Role of microRNAs

5. Curcumin inhibits the development of non small cell lung cancer by inhibiting autophagy and apoptosis

6. Exploration of inhibitory mechanisms of curcumin in lung cancer metastasis using a miRNA- transcription factor-target gene network

7. Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction

8. Curcumin sensitizes human lung cancer cells to apoptosis and metastasis synergistically combined with carboplatin

9. Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway

10. Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway

11. Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1

12. Curcumin Induces Apoptosis of Upper Aerodigestive Tract Cancer Cells by Targeting Multiple Pathways

13. Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro

14. Potential anti-cancer effect of curcumin in human lung squamous cell carcinoma

15. Curcumin induces the apoptosis of non-small cell lung cancer cells through a calcium signaling pathway

16. Curcumin Blocks Small Cell Lung Cancer Cells Migration, Invasion, Angiogenesis, Cell Cycle and Neoplasia through Janus Kinase-STAT3 Signalling Pathway

17. The role of curcumin in response to BPDE-induced DNA damage in human lung epithelial cells.

18. Curcumin Induces Apoptosis in Human Non-small Cell Lung Cancer NCI-H460 Cells through ER Stress and Caspase Cascade- and Mitochondria-dependent Pathways

In Vivo

1. Curcumin inhibits human non-small cell lung cancer xenografts by targeting STAT3 pathway

2. Identification of curcumin-inhibited extracellular matrix receptors in non–small cell lung cancer A549 cells by RNA sequencing

3. Synergistic effect of fenretinide and curcumin for treatment of non-small cell lung cancer

4. Translating Curcumin to the Clinic for Lung Cancer Prevention: Evaluation of the Preclinical Evidence for Its Utility in Primary, Secondary, and Tertiary Prevention Strategies

5. Curcumin Lowers Erlotinib Resistance in Non-Small Cell Lung Carcinoma Cells With Mutated EGF Receptor

6. Study to Evaluate Molecular Mechanics behind Synergistic Chemo-Preventive Effects of Curcumin and Resveratrol during Lung Carcinogenesis

7. Curcumin: A Novel Stat 3 Pathway Inhibitor for Chemoprevention of Lung Cancer

8. Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer

9. Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of 1-antitrypsin in lung cancer

10. Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy

11. Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer

12. Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1

Lymphoma

1. Curcuma Contra Cancer? Curcumin and Hodgkin’s Lymphoma

2. Oxidative Stress Induced by Curcumin Promotes the Death of Cutaneous T-cell Lymphoma (HuT-78) by Disrupting theFunction of Several Molecular Targets

3. Curcumin Selectively Induces Apoptosis in Cutaneous T-Cell Lymphoma Cell Lines and Patients’ PBMCs: Potential Role for STAT-3 and NF-jB Signaling

Renal Cell Carcinoma

1. Curcumin enhances temsirolimus-induced apoptosis in human renal carcinoma cells through upregulation of YAP/p53

2. Influence of Curcumin on HOTAIR-Mediated Migration of Human Renal Cell Carcinoma Cells

Skin Cancer

1. Inhibitory Effect of Curcumin on Invasion of Skin Squamous Cell Carcinoma A431 Cells

2. Curcumin Inhibits Skin Squamous Cell Carcinoma Tumor Growth In Vivo

Stomach Cancer

In Vitro

1. Curcumin suppresses gastric cancer by inhibiting gastrin-mediated acid secretion

2. Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics

3. Enhancing Effects of Curcumin on Cytotoxicity of Paclitaxel, Methotrexate and Vincristine in Gastric Cancer Cells

4. Strategy to enhance efficacy of doxorubicin by curcumin as a potent Pgp inhibitor in gastric cancer

5. Curcumin sensitizes human gastric cancer cells to 5-fluorouracil through inhibition of the NFκB survival-signaling pathway

6. Combinational Treatment of Curcumin and Quercetin against Gastric Cancer MGC-803 Cells in Vitro

7. Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19

8. Synergistic anticancer effect of curcumin and chemotherapy regimen FP in human gastric cancer MGC 803 cells

9. Curcumin inhibits proliferation of gastric cancer cells by impairing ATP-sensitive potassium channel opening

10. Curcumin reverses chemoresistance of human gastric cancer cells by downregulating the NF-κB transcription factor

11. Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression

In Vivo

1. Curcumin Enhances the Anticancer Effect Of 5-fluorouracil against Gastric Cancer through Down-Regulation of COX-2 and NF- κB Signaling Pathways

2. pH Triggered Curcumin Release from PMMA-AA Coated ZnO Nanoparticles for Excellent Anti-Gastric Cancer Therapy

3. Curcumin Enhances the Effects of 5-Fluorouracil and Oxaliplatin in Inducing Gastric Cancer Cell Apoptosis Both In Vitro and In Vivo

4. Curcumin Attenuates Gastric Cancer Induced by N-Methyl-N-Nitrosourea and Saturated Sodium Chloride in Rats

Clinical Trial

1. Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

Thyroid Cancer

1. Effects of different extracts of curcumin onTPC1 papillary thyroid cancer cell line

2. Radiosensitive effect of curcumin on thyroid cancer cell death induced by radioiodine-131

3. Curcumin Enhances Docetaxel-Induced Apoptosis of 8505C Anaplastic Thyroid Carcinoma Cells