Resveratrol

General Anti-cancer Activities

Bladder Cancer

1.Effect and mechanism of resveratrol on drug resistance in human bladder cancer cells

2.Resveratrol induces apoptosis associated with mitochondrial dysfunction in bladder carcinoma cells

Bone Cancer

1.Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity

2.Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3 kinase/AKT and p38 mitogen-activated protein kinase pathways

3.Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma Cells

4.Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

Brain Cancer

1.Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway

2.Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways

3.Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells

4.Inhibition of STAT3Expression and Signaling in Resveratrol-Differentiated Medulloblastoma Cells

Colorectal Cancer

1.Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/-Catenin Signal Pathway

2.Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis

3.Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways

Esophageal Cancer

In Vitro

1.Resveratrol mediates cell cycle arrest and cell death in human esophageal squamous cell carcinoma by directly targeting the EGFR signaling pathway

2.Resveratrol Inhibits Oesophageal Adenocarcinoma Cell Proliferation via AMP-activated Protein Kinase Signaling

3.Resveratrol induces apoptosis in human esophageal carcinoma cells

4.Resveratrol Induces Growth Inhibition, S-phase Arrest, Apoptosis, and Changes in Biomarker Expression in Several Human Cancer Cell Lines

In Vivo

1.Resveratrol synergistically augments anti-tumor effect of 5-FU in vitro and in vivo by increasing S-phase arrest and tumor apoptosis

2.Suppression of N-nitrosomethylbenzylamine (NMBA)- induced esophageal tumorigenesis in F344 rats by resveratrol

Clinical trial

1.A dietary pattern rich in lignans, quercetin and resveratrol decreases the risk of oesophageal cancer

Liver Cancer

In Vitro

1.Novel combination of thymoquinone and resveratrol enhances anticancer effect on hepatocellular carcinoma cell line

2.Resveratrol inhibits proliferation and migration through SIRT1 mediated post translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells

3.Resveratrol enhances anticancer effects of paclitaxel in HepG2 human liver cancer cells

4.Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway

5.Potentiation of resveratrol-induced apoptosis by matrine in human hepatoma HepG2 cells

6.Synergistic anticancer effects of curcumin and resveratrol in Hepa1-6 hepatocellular carcinoma cells

7.The Antimetastatic Effects of Resveratrol on Hepatocellular Carcinoma through the Downregulation of a Metastasis-Associated Protease by SP-1 Modulation

8.Resveratrol Induces Apoptosis in Human SK-HEP-1 Hepatic Cancer Cells

9.Anti-hepatoma activity of resveratrol in vitro

In Vivo

1.Influence of resveratrol on liver fibrosis induced by dimethylnitrosamine in male rats

2.Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway

3.Anticancer properties of resveratrol on chemically induced hepatocellular carcinoma in rats: Inhibition of metastasis and angiogenesis

4.By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice

5.Resveratrol and cancer: focus on in vivo evidence

6.Resveratrol and liver: A systematic review

7.Chemoprevention of HBV-related hepatocellular carcinoma by the combined product of resveratrol and silymarin in transgenic mice

8.Resveratrol Downregulates Cyp2e1 and Attenuates Chemically Induced Hepatocarcinogenesis in SD Rats

9.Resveratrol Helps Recovery from Fatty Liver and Protects against Hepatocellular Carcinoma Induced by Hepatitis B Virus X Protein in a Mouse Model

10.Angioprevention is Implicated in Resveratrol Chemoprevention of Experimental Hepatocarcinogenesis

11.Resveratrol Suppresses Oxidative Stress and Inflammatory Response in Diethylnitrosamine-Initiated Rat Hepatocarcinogenesis

Lung Cancer

In Vitro

1.Resveratrol raises in vitro anticancer effects of paclitaxel in NSCLC cell line A549 through CO X-2 expression

2.Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells

3.Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis

4.Resveratrol Enhances Etoposide-Induced Cytotoxicity through Down-Regulating ERK1/2 and AKT-Mediated X-ray Repair Cross-Complement Group 1 (XRCC1) Protein Expression in Human Non-Small-Cell Lung Cancer Cells

5.Anti-Inflammatory and Pro-apoptotic Effects of Curcumin and Resveratrol on the Human Lung Fibroblast Cell Line MRC-5

6.Resveratrol Modulates Expression of ABC Transporters in Non-Small Lung Cancer Cells: Molecular Docking and Gene Expression Studies

7.Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage

8.Resveratrol Alters microRNA Expression Profiles in A549 Human Non-Small Cell Lung Cancer Cells

9.Molecular Mechanisms of Resveratrol Action in Lung Cancer Cells Using Dual Protein and Microarray Analyses

10.Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells

11.Resveratrol Enhances Radiosensitivity of Human Non-Small Cell Lung Cancer NCI-H838 Cells Accompanied by Inhibition of Nuclear Factor-Kappa B Activation

In Vivo

1.Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies

2.Resveratrol in lung cancer- a systematic review

3.Study to Evaluate Molecular Mechanics behind Synergistic Chemo-Preventive Effects of Curcumin and Resveratrol during Lung Carcinogenesis

4.In vitro and in vivo Evaluation of the Antitumor Efficiency of Resveratrol Against Lung Cancer

5.Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[alpha]pyrene

Ovarian Cancer

1.Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells

2.Resveratrol Inhibits Cisplatin-Induced Epithelial-to-Mesenchymal Transition in Ovarian Cancer Cell Lines

3.Resveratrol Exerts Differential Effects in Vitro and in Vivo against Ovarian Cancer Cells

4.Resveratrol Suppresses Growth of Human Ovarian Cancer Cells in Culture and in a Murine Xenograft Model: Eukaryotic Elongation Factor 1A2 as a Potential Target

Pancreatic Cancer

1.In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells

2.Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway

3.Resveratrol, a Red Wine Polyphenol, Suppresses Pancreatic Cancer by Inhibiting Leukotriene A4 Hydrolase

4.Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer

Prostate Cancer

In Vitro

1.Resveratrol- activates autophagic cell death in prostate cancer cells via down regulation of STIM1 and the mTOR pathway

2.Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway

3.Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer

4.Resveratrol suppresses the epithelial-to-mesenchymal transition in PC-3 cells by down-regulating the PI3K/AKT signaling pathway

5.Resveratrol Activates Autophagic Cell Death in Prostate Cancer Cells via Downregulation of STIM1 and the mTOR Pathway

6.Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells

7.A novel anti cancer effect of resveratrol: reversal of epithelial mesenchymal transition in prostate cancer cells

8.Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis

9.Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of theAMPK, Akt and mTOR pathways

10.Combination of Resveratrol and Antiandrogen Flutamide Has Synergistic Effect on Androgen Receptor Inhibition in Prostate Cancer Cells

11.Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

12.Antiproliferative Effects of Resveratrol and the Mediating Role of Resveratrol Targeting Protein NQO2 in Androgen Receptor positive, Hormone-non-responsive CWR22Rv1 Cells

13.Repressive Effects of Resveratrol on Androgen Receptor Transcriptional Activity

14.Resveratrol Down-Regulates the Androgen Receptor at the Post-Translational Level in Prostate Cancer Cells

15.Mechanisms Involved in Resveratrol-Induced Apoptosis and Cell Cycle Arrest in Prostate Cancer–Derived Cell Lines

16.Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3’-kinase/Akt pathway and Bcl-2 family proteins

17.Resveratrol Induces Prostate Cancer Cell Entry into S Phase and Inhibits DNA Synthesis

18.Resveratrol Inhibits the Expression and Function of the Androgen Receptor in LNCaP Prostate Cancer Cells

In Vivo

1.Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer

2.Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer

3.Resveratrol–zinc combination for prostate cancer management

4.Dietary Resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: Involvement of SIRT1/S6K axis

5.Resveratrol Reduces Prostate Cancer Growth and Metastasis by Inhibiting the Akt/MicroRNA-21 Pathway

6.Apoptosis by dietary agents for prevention and treatment of prostate cancer

7.Suppression of Prostate Cancer Growth by Resveratrol in The Transgenic Rat for Adenocarcinoma of Prostate (TRAP) Model

8.Resveratrol suppresses prostate cancer progression in transgenic mice

Renal Cell Carcinoma

1.Resveratrol attenuates constitutive STAT3and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma

2.Resveratrol promotes regression of renal carcinoma cells via a renin- angiotensin system suppression dependent mechanism

3.Effects of Resveratrol on Gene Expression in Renal Cell Carcinoma

Skin Cancer

1.Administration of resveratrol enhances cell-cycle arrest followed by apoptosis in DMBA-induced skin carcinogenesis in male Wistar rats

2.Resveratrol Modulates the Malignant Properties of Cutaneous Melanoma via Changes in the Activation and Attenuation of the Anti-apoptotic Proto-oncogenic Protein Akt/PKB

3.The Grape Antioxidant Resveratrol for Skin Disorders: Promise, Prospects, and Challenges

Stomach Cancer

In Vitro

1.Mediation of the Anticancer Effects of Resveratrol via the Upregulation of Tristetraprolin in Gastric Cancer Cell

2.Expression of genes and proteins of multidrug resistance in gastric cancer cells treated with resveratrol

3.Resveratrol induces apoptosis in SGC 7901 gastric cancer cells

4.Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway

5.Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer

6.Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN-regulated PI3K/Akt signaling pathway

7.Effects of resveratrol on the protein expression of survivin and cell apoptosis in human gastric cancer cells

8.Inhibition of Sphingolipid Metabolism Enhances Resveratrol Chemotherapy in Human Gastric Cancer Cells

9.The genotoxicity study of resveratrol in primary gastric adenocarcinoma cell cultures

10.Inhibition of gastric cancer cell proliferation by resveratrol: role of nitric oxide

In Vivo

1.Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer

2.Resveratrol: A potential challenger against gastric cancer

3.Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner

Thyroid Cancer

1.Resveratrol Sensitizes Selectively Thyroid Cancer Cell to131-Iodine Toxicity

2.Resveratrol Induces Differentiation Markers Expression in Anaplastic Thyroid Carcinoma via Activation of Notch1Signaling and Suppresses Cell Growth

3.Resveratrol Induces Apoptosis in Thyroid Cancer Cell Lines via a MAPK- and p53-Dependent Mechanism