Pomegranate

Bladder Cancer

5) Deciphering the Molecular Mechanism Underlying the Inhibitory Efficacy of Taiwanese Local Pomegranate Peels against Urinary Bladder Urothelial Carcinoma (2018)

6) Urolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cells (2017)

7) Clarification of the molecular pathway of Taiwan local pomegranate fruit juice underlying the inhibition of urinary bladder urothelial carcinoma cell by proteomics strategy (2016)

8) Anti-Proliferative Effects of Polyphenols from Pomegranate Rind (Punica granatum L.) on EJ Bladder Cancer Cells Via Regulation of p53/miR-34a Axis (2015)

9) Suppression of urinary bladder urothelial carcinoma cell by the ethanol extract of pomegranate fruit through cell cycle arrest and apoptosis (2013)

Brain Cancer

1) Inhibition of glioblastoma proliferation, invasion, and migration by Urolithin B through inducing G0/G1 arrest and targeting MMP-2/-9 expression and activity (2023)

2) PDIA3 Expression in Glioblastoma Modulates Macrophage/Microglia Pro-Tumor Activation (2020)

3) The Effect of Pomegranate Juice on the Invasion and Migration of Glioma Cells (2020)

4) Punicic Acid Inhibits Glioblastoma Migration and Proliferation via the PI3K/AKT1/mTOR Signaling Pathway (2019)

5) Pomegranate seed oil nanoemulsions with selective antiglioma activity: optimization and evaluation of cytotoxicity, genotoxicity and oxidative effects on mononuclear cells (2016)

6) Punicalagin induces apoptotic and autophagic cell death in human U87MG glioma cells (2013)

Breast Cancer

Cervical Cancer

1) Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer (2023)

2) Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway (2022)

3) Punicalin and ellagic acid from pomegranate peel extract facilitate apoptotic behaviour in the Hela cell line (2021)

4) Punicalagin promotes the apoptosis in human cervical cancer (ME-180) cells through mitochondrial pathway and by inhibiting the NF-kB signaling pathway (2020)

5) Punicalagin suppresses the proliferation and invasion of cervical cancer cells through inhibition of the β-catenin pathway (2017)

6) Inhibition of Cervical Cancer by Promoting IGFBP7 Expression Using Ellagic Acid from Pomegranate Peel (2016)

Colorectal Cancer

In Vitro

1) Determination of the Antioxidant and Antiproliferative Properties of Pomegranate Peel Extract Obtained by Ultrasound on HCT-116 Colorectal Cancer Cell Line (2023)

2) Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells (2021)

3) The gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells(2020)

4) Punicalagin Regulates Apoptosis-Autophagy Switch via Modulation of Annexin A1 in Colorectal Cancer (2020)

5) Antitumor and Antimicrobial activities of pomegranate (Punica granatum) dried powder peel in vitro (2019)

6) Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells (2018)

7) Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins (2010)

8) THE ROLE OF POMEGRANATE (PUNICA GRANATUM L.) IN COLON CANCER (2009)

9) Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells (2006)

10) The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway (2006)

In Vivo

1) Modulatory effect of pomegranate extract on TRPA1, TRPM2 and caspase-3 expressions in colorectal cancer induction of mice (2022)

2) Granatin B and punicalagin from Chinese herbal medicine pomegranate peels elicit reactive oxygen species-mediated apoptosis and cell cycle arrest in colorectal cancer cells (2022)

3) Therapeutic Effect of Pomegranate (Punica granatum) Juice and Peel Water Extract on Colon Cancer in Experimental rats (2022)

4) Pomegranate (Punica granatum) Fruit Extract Suppresses Cancer Progression and Tumor Angiogenesis of Pancreatic and Colon Cancer in Chick Chorioallantoic Membrane Model (2020)

5) Pomegranate By-Products in Colorectal Cancer Chemoprevention: Effects in Apc-Mutated Pirc Rats and Mechanistic Studies In Vitro and Ex Vivo (2018)

6) Punica granatum suppresses colon cancer through downregulation of Wnt/β-Catenin in rat model (2017)

7) Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR (2013)

8) Inhibitory Effect of a Standardized Pomegranate Fruit Extract on Wnt Signalling in 1, 2-Dimethylhydrazine Induced Rat Colon Carcinogenesis (2013)

9) Pomegranate (Punica granatum) Peel Extract Efficacy as a Dietary Antioxidant against Azoxymethane-Induced Colon Cancer in Rat (2012)

10) Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats (2004)

Clinical Trials

1) Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial (2017)

2) MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts (2015)

Review

1) Medicinal plants with anti-colorectal cancer bioactive compounds: Potential game-changers in colorectal cancer management (2022)

2) Role of pomegranate and citrus fruit juices in colon cancer Prevention (2014)

Leukemia

1) Punicalagin, a pomegranate compound, induces apoptosis and autophagy in acute leukemia (2021)

2) Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells (2021)

3) Characterization of pomegranate peel extracts obtained using different solvents and their effects on cell cycle and apoptosis in leukemia cells (2020)

4) Inhibition of telomerase activity and cell growth by free and nanoliposomal forms of punicalagin in human leukemia cell line K562 (2016)

5) Growth inhibitory effects of crude pomegranate peel extract on chronic myeloid leukemia, K562 cells (2015)

6) Polyphenols are responsible for the proapoptotic properties of pomegranate juice on leukemia cell lines (2013)

7) Bioactive Actions of Pomegranate Fruit Extracts on Leukemia Cell Lines In Vitro Hold Promise for New Therapeutic Agents for Leukemia (2012)

8) Cytotoxicity of extracts from fruit plants against leukemic cell lines (2010)

9) Differentiation-Promoting Activity of Pomegranate (Punica granatum) Fruit Extracts in HL-60 Human Promyelocytic Leukemia Cells (2004)

Liver Cancer

In Vitro

1) Pomegranate Peel Extract Sensitizes Hepatocellular Carcinoma Cells to Ionizing Radiation, Induces Apoptosis and Inhibits MAPK, JAK/STAT3, β-Catenin/NOTCH, and SOCS3 Signaling (2023)

2) Pomegranate Seeds and Peel Ethanolic Extracts Anticancer Potentials and Related Genetic, Histological, Immunohistochemical, Apoptotic and Oxidative Stress Profiles: In vitro Study (2023)

3) Nanoparticles of Punicalagin Synthesized from Pomegranate (Punica Granatum L.) with Enhanced Efficacy Against Human Hepatic Carcinoma Cells (2021)

4) Green Synthesis of Gold Nanoparticles Using Pomegranate Peel Extract and Its Antioxidant and Anticancer Activity against Liver Cancer Cell Line (2020)

5) Punicalagin and ellagic acid from pomegranate peel induce apoptosis and inhibits proliferation in human HepG2 hepatoma cells through targeting mitochondria (2019)

6) Pomegranate peel extract polyphenols induced apoptosis in human hepatoma cells by mitochondrial pathway (2016)

In Vivo

1) Pomegranate juice and punicalagin mediated chemoprevention of hepatocellular carcinogenesis via regulating miR‑21 and NF‑κB‑p65 in a rat model (2022)

2) Chemopreventive Efficacy of Punica granatum and Silybum marianum Extracts on Chemically-induced Hepatocellular Carcinoma in Rats (2019)

3) Effect of Pomegranate Hull Extract on Liver Neoplastic Changes in Rats: More than an Antioxidant (2016)

4) HEPATOPROTECTIVE EFFECTS OF POMEGRANATE AND APPLE JUICES AGAINST N-NITROSODIETHYLAMINE- INDUCED HEPATOCELLULAR CARCINOMA IN MALE RATS (2016)

5) Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis (2013)

6) Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/-Catenin Signaling Pathway (2013)

7) Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms (2011)

Lung Cancer

In Vitro

1) Urolithin A Inhibits Epithelial–Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2- Snail Pathway (2021)

2) Punicalagin induces ROS‐mediated apoptotic cell death through inhibiting STAT3 translocation in lung cancer A549 cells (2021)

3) Punicalagin induces apoptosis in A549 cell line through mitochondria-mediated pathway(2020)

4) Evaluation of the antioxidant, antibacterial and anticancer (lung cancer cell line A549) activity of Punica granatum mediated silver nanoparticles (2018)

5) Pomegranate Juice Induced Cell Cycle Arrest and Apoptosis Via Mitochondrial Pathway in Human Lung Aden carcinoma A549 Cells (2018)

6) Punica granatum (pomegranate) leaves extract induces apoptosis through mitochondrial intrinsic pathway and inhibits migration and invasion in non-small cell lung cancer in vitro (2016)

7) ORNITHINE DECARBOXYLASE GENE EXPRESSION IN HUMAN LUNG ADENOCARCINOMA CELL (A549) TREATED WITH POMEGRANATE JUICE (2015)

8) Anti-proliferative activity and protection against oxidative DNA damage by punicalagin isolated from pomegranate husk (2012)

In Vivo

1) Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model (2017)

2) Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice (2007)

3) Oral Consumption of Pomegranate Fruit Extract Inhibits Growth and Progression of Primary Lung Tumors in Mice (2007)

Review

1) Therapeutic properties of Punica granatum L (pomegranate) and its applications in lung-based diseases: A detailed review (2021)

2) An Insight of Polyphenols in Lung Cancer Chemoprevention (2018)

3) Dietary agents for prevention and treatment of lung cancer (2015)

Oral Cancer

1) Antitumoral properties of the pomegranate peel and blueberry extracts against tongue carcinoma (in vitro study) (2023)

2) EFFECT OF POMEGRANATE EXTRACT AND ITS NANOPARTICLES ON HUMAN TONGUE SQUAMOUS CELL CARCINOMA CELL LINE (2023)

3) Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review (2022)

4) Pomegranate Extract (POMx) Induces Mitochondrial Dysfunction and Apoptosis of Oral Cancer Cells (2021)

5) Pomegranate extract inhibits migration and invasion of oral cancer cells by downregulating matrix metalloproteinase-2/9 and epithelial-mesenchymal transition (2020)

6) Assessment of Anti-carcinogenic Effect of Pomegranate in Oral Squamous Cell Carcinoma (Pre-clinical Study) (2019)

7) Evaluation of the Secondary Metabolites of the Waste Pomegranate Rind and its Cytotoxicity against Oral Cancer (KB 3-1) (2019)

8) THE EFFICACY OF POMEGRANATE EXTRACT (PUNICA GRANATUM L.) AND ELLAGIC ACID ON THE EXPRESSION OF VEGF AND ORAL CANCER CELLS APOPTOSIS OF MUS MUSCULUS DUE TO BENZOPYRENE INDUCTION (2019)

9) The inhibition of malignant epithelial cells in mucosal injury in the oral cavity of strains by pomegranate fruit extract (Punica granatum linn) through Bcl-2 expression (2013)

10) Pomegranate Extract, A Prooxidant with Antiproliferative and Proapoptotic Activities Preferentially Towards Carcinoma Cells (2010)

Ovarian Cancer

1) Effect of Pomegranate peel extract on expression of angiogenesis stimulating gene (VEGF) in A2780 cell line of ovarian cancer (2020)

2) POLYPHENOL-RICH POMEGRANATE EXTRACT AS A POTENTIAL MODULATOR OF STEROIDOGENESIS IN HUMAN OVARIAN CELLS (2019)

3) Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9 (2017)

4) Anti Tumoral Properties of Punica granatum (Pomegranate) Seed Extract in Different Human Cancer Cells (2016)

5) Therapeutic Effects of Punicalagin Against Ovarian Carcinoma Cells in Association With A-Catenin Signaling Inhibition (2016)

Pancreatic Cancer

1) Remodeling of Stromal Immune Microenvironment by Urolithin A Improves Survival with Immune Checkpoint Blockade in Pancreatic Cancer (2023)

2) Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines (2023)

3) Herbals and Plants in the Treatment of Pancreatic Cancer: A Systematic Review of Experimental and Clinical Studies (2022)

4) Pomegranate (Punica granatum) Fruit Extract Suppresses Cancer Progression and Tumor Angiogenesis of Pancreatic and Colon Cancer in Chick Chorioallantoic Membrane Model (2020)

5) Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer (2019)

6) The effect of pomegranate juice extract on the Hedgehog signaling pathway in pancreatic cancer (2014)

7) Pomegranate Extract Induces Cell Cycle Arrest and Alters Cellular Phenotype of Human Pancreatic Cancer Cells (2011)

Prostate Cancer

In Vitro

1) Evaluation of the Antioxidant and Antiangiogenic Activity of a Pomegranate Extract in BPH-1 Prostate Epithelial Cells (2023)

2) EFFECT OF POMEGRANATE EXTRACT GALLIC ACID ON THE PROLIFERATION OF PROSTATE CANCER CELLS BY PROMOTING THE EXPRESSION OF IGFBP7 (2020)

3) Growth Inhibitory and Pro-Apoptotic Effects of Ornamental Pomegranate Extracts in Du145 Human Prostate Cancer Cells (2019)

4) Punicalagin, a polyphenol from pomegranate fruit, induces growth inhibition and apoptosis in human PC-3 and LNCaP cells (2017)

5) The extract from Punica granatum (pomegranate) peel induces apoptosis and impairs metastasis in prostate cancer cells (2017)

6) Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis (2013)

7) Specific Pomegranate Juice Components as Potential Inhibitors of Prostate Cancer Metastasis (2012)

8) Proteomic exploration of the impacts of pomegranate fruit juice on the global gene expression of prostate cancer cell (2012)

9) Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells (2011)

10) Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF–IGFBP axis (2010)

11) Growth Inhibitory, Antiandrogenic, and Pro-apoptotic Effects of Punicic Acid in LNCaP Human Prostate Cancer Cells (2010)

12) Effects of Pomegranate Chemical Constituents/Intestinal Microbial Metabolites on CYP1B1 in 22Rv1 Prostate Cancer Cells (2009)

13) Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor (2008)

14) Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions (2005)

15) Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across MatrigelTM (2005)

In Vivo

1) Urolithin A induces prostate cancer cell death in p53‑dependent and in p53‑independent manner (2019)

2) Effect of Pomegranate Peel Polyphenols on Human Prostate Cancer PC-3 cells in vivo (2015)

3) Pomegranate extracts impact the androgen biosynthesis pathways inprostate cancer models in vitro and in vivo (2014)

4) Luteolin, ellagic acid and punicic acid are natural products that inhibit prostate cancer Metastasis (2014)

5) Pomegranate Extract Inhibits the Bone Metastatic Growth of Human Prostate Cancer Cells and Enhances the In Vivo Efficacy of Docetaxel Chemotherapy (2014)

6) EllagicAcid, a Component of Pomegranate Fruit Juice, Suppresses Androgen-Dependent Prostate Carcinogenesis via Induction of Apoptosis (2014)

7) Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model (2012)

8) Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo (2008)

9) Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-KB-dependent mechanism (2008)

10) Pomegranate Ellagitannin-Derived Metabolites Inhibit Prostate Cancer Growth and Localize to the Mouse Prostate Gland (2007)

11) Prostate Cancer Prevention Through Pomegranate Fruit (2006)

12) Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer (2005)

13) Pomegranate Extracts Potently Suppress Proliferation, Xenograft Growth, and Invasion of Human Prostate Cancer Cells (2004)

Clinical Trials

1) A phase II randomized placebo‐controlled trial of pomegranate fruit extract in men with localized prostate cancer undergoing active surveillance (2020)

2) A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer (2013)

3) A Double-Blind, Randomized, Neoadjuvant Study of the Tissue Effects of POMx Pills in Men with Prostate Cancer Before Radical Prostatectomy (2013)

4) Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice (2010)

5) Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer (2006)

Review

1) Pomegranate (Punica granatum) derived phytochemical actions towards prostate cancer (2022)

2) Plant Bioactives and the Prevention of Prostate Cancer: Evidence from Human Studies (2019)

3) A review of pomegranate in prostate cancer (2017)

4) Role of Pomegranate in Regulation of Genes and Mechanisms of Prostate Cancer Metastasis: A Review (2015)

5) Pomegranate and Its Components as Alternative Treatment for Prostate Cancer (2014)

6) Pomegranate Extracts in the Management of Men’s Urologic Health: Scientific Rationale and Preclinical and Clinical Data (2013)

7) Usefulness of pomegranate in prostate cancer (2012)

8) Nutraceuticals and prostate cancer prevention: a current review (2010)

9) Ellagic acid, pomegranate and prostate cancer – a mini review (2008)

10) Anti-Oxidants from Green Tea and Pomegranate for Chemoprevention of Prostate Cancer (2007)

11) Clinical trials of natural products as chemopreventive agents for prostate cancer (2006)

12) Polyphenols from green tea and pomegranate for prevention of prostate cancer (2006)

Skin Cancer

In Vitro

1) Inhibitory Effect of Dried Pomegranate Concentration Powder on Melanogenesis in B16F10 Melanoma Cells; Involvement of p38 and PKA Signaling Pathways (2015)

2) Photochemopreventive Effect of Pomegranate Fruit Extract on UVA-mediated Activation of Cellular Pathways in Normal Human Epidermal Keratinocytes (2006)

3) Pomegranate Fruit Extract Modulates UV-6-mediated Phosphorylation of Mitogen-activated Protein Kinases and Activation of Nuclear Factor Kappa B in Normal Human Epidermal Keratinocyte (2005)

In Vivo

1) Chemopreventive effect of pomegranate and cocoa extracts on ultraviolet radiation induced photocarcinogenesis in SKH-1 mice (2020)

2) Standardized Punica Granatum Pericarp Extract, Suppresses Tumor Proliferation and Angiogenesis in a Mouse Model of Melanoma: Possible Involvement of PPARα and PPARγ Pathways (2019)

3) Pomegranate Fruit Extract Inhibits UVB-induced Inflammation and Proliferation by Modulating NF-B and MAPK Signaling Pathways in Mouse Skin (2011)

4) Synergistic growth inhibition of mouse skin tumors by pomegranate fruit extract and diallyl sulfide: Evidence for inhibition of activated MAPKs/NF-B and reduced cell proliferation (2011)

5) Oral Feeding of Pomegranate Fruit Extract Inhibits Early Biomarkers of UVB Radiation-induced Carcinogenesis in SKH-1 Hairless Mouse Epidermis (2010)

6) Anthocyanin- and Hydrolyzable Tannin-Rich Pomegranate Fruit Extract Modulates MAPK and NF-B Pathways and Inhibits Skin Tumorigenesis in CD-1 Mice (2005)

7) Chemopreventive Effects of Pomegranate Seed Oil on Skin Tumor Development in CD1 Mice (2003)

Review

1) An Update on the Role of Dietary Phytochemicals in Human Skin Cancer: New Insights into Molecular Mechanisms (2020)

2) Whole Fruit Phytochemicals Combating Skin Damage and Carcinogenesis (2020)

3) New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals: In Vitro and In Vivo Studies and the Underlying Mechanisms (2014)

4) Polyphenols: Skin Photoprotection and Inhibition of Photocarcinogenesis (2011)

Stomach Cancer

1) Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway (2023)

2) Green immobilized Ag NPs over magnetic Fe3O4 NPs using Pomegranate juice induces apoptosis via P53 and signal transducer and activator of transcription 3 signaling pathways in human gastric cancer cells (2022)

3) The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells (2022)

4) Anticancer Effects of Blueberry and Pomegranate Extracts on the AGS Gastric Adenocarcinoma Cell Line (2014)

Thyroid Cancer

1) Phytochemicals in thyroid cancer: analysis of the preclinical studies (2021)

2) Plant natural products with anti-thyroid cancer activity (2020)

3) Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells via NF-κB signaling pathway (2018)

4) Punicalagin from pomegranate promotes human papillary thyroid carcinoma BCPAP cell death by triggering ATM-mediated DNA damage response (2017)

5) Punicalagin induces apoptosis-independent autophagic cell death in human papillary thyroid carcinoma BCPAP cells (2016)