Lycopene

General Anti-cancer Activities

1. Multiple Molecular and Cellular Mechanisms of Action of Lycopene in Cancer Inhibition

2. Lycopene metabolism and its biological significance

3. Lycopene as a guardian of redox signaling

4. An Update on the Health Effects of Tomato Lycopene

5. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines

6. Antioxidant and anti-proliferative properties of lycopene

7. Biological activity of lycopene metabolites: implications for cancer prevention

8. Attack of the Killer Tomatoes: Lycopene and Cancer Prevention

Breast Cancer

1. In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells

2. Lycopene and Beta-carotene Induce Cell-Cycle Arrest and Apoptosis in Human Breast Cancer Cell Lines

3. Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines

Lung Cancer

In Vitro

1. The effect of Lycopene as Immunotherapy and Immuno-modulatory in Lung Cancer, Tumor and Autoimmunity Treatment and Prevention

2. Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines

In Vivo

1. Can Smoke-Exposed Ferrets Be Utilized to Unravel the Mechanisms of Action of Lycopene?

2. Lycopene Supplementation Inhibits Lung Squamous Metaplasia and Induces Apoptosis via Up-Regulating Insulin-like Growth Factor-binding Protein 3 in Cigarette Smoke-exposed Ferrets

Clinical Trial

1. Tomato Lycopene and Lung Cancer Prevention: From Experimental to Human Studies

Oral Cancer

In Vitro

1. Synergic effect of curcumin or lycopene with irradiation upon oral squamous cell carcinoma cells (2013)

2. Lycopene Inhibits Proliferation and Enhances Gap-Junction Communication of KB-1 Human Oral Tumor Cells (2002)

In Vivo

1. Effect of Lycopene on Oral Squamous Cell Carcinoma Cell Growth by Inhibiting IGF1 Pathway (2021)

2. Lycopene Inhibits Epithelial–Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway (2020)

3. Histological and immunohistochemical evaluation of the chemopreventive role of lycopene in tongue carcinogenesis induced by 4-nitroquinoline-1-oxide (2011)

Clinical Trials

1. To determine the efficacy of lycopene as compared to multivitamin preparation in the treatment of Oral Submucous Fibrosis (2017)

2. Comparative study of the efficacy of lycopene and aloe vera in the treatment of oral submucous Fibrosis (2015)

3. Randomized controlled trial to evaluate the efficacy of oral lycopene in combination with vitamin E and selenium in the treatment of oral leukoplakia (2014)

4. LYCOPENE IN THE MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS (2013)

5. The Response of Oral Submucous Fibrosis to Lycopene – A Carotenoid Antioxidant: A Clinicopathological Study (2011)

6. Efficacy of lycopene in the management of oral submucous Fibrosis (2007)

7. Low Plasma Lycopene Concentration is Associated with Increased Mortality in a Cohort of Patients with Prior Oral, Pharynx or Larynx Cancers (2004)

8. Oral lycopene — an efficacious treatment for oral leukoplakia? (2004)

9. Efficacy of oral lycopene in the treatment of oral leukoplakia (2004)

10. Response of lycopene in treatment of oral submucous fibrosis

Meta-analysis & Review

1. Efficacy of lycopene in management of Oral Submucous Fibrosis– A systematic review and meta-analysis (2020)

2. Role of lycopene in oral potentially malignant disorders (2017)

3. Role of lycopene in the prevention of oral precancerous lesions. A Review (2017)

4. Anti‐inflammatory Dietary Supplements in the Chemoprevention of Oral Cancer. (2016)

5. LYCOPENE: POTENT ANTIOXIDANT FOR ORAL PREMALIGNANCY AND ORAL CANCER (2015)

6. Role of Lycopene in Preventing Oral Diseases as a Nonsurgical Aid of Treatment (2015)

7. LYCOPENE – ROLE IN CANCER PREVENTION (2013)

8. Lycopene in oral health (2013)

Prostate Cancer

In Vitro

1. Lycopene Treatment of Prostate Cancer Cell Lines Inhibits Adhesion and Migration Properties of the Cells

2. Effects of Lycopene on Protein Expression in Human Primary Prostatic Epithelial Cells

3. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines

In Vivo

1. Tomatoes or Lycopene: a Role in Prostate Carcinogenesis?

Clinical Trials

1. Tomato consumption and prostate cancer risk: a systematic review and meta-analysis

2. Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA

3. Lycopene and Risk of Prostate Cancer

4. Effect of Carotene and Lycopene on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies

5. The Potential Role of Lycopene for the Prevention and Therapy of Prostate Cancer: From Molecular Mechanisms to Clinical Evidence

6. Lycopene, Tomato Products, and Prostate Cancer Incidence: A Review and Reassessment in the PSA Screening Era

7. Lycopene/Tomato Consumption and the Risk of Prostate Cancer: A Systematic Review and Meta-analysis of Prospective Studies

8. Tomato Products, Lycopene, and Prostate Cancer: A Review of the Epidemiological Literature

9. Lycopene and prostate cancer

10. Tomato Phytochemicals and Prostate Cancer Risk

11. Tomatoes, Lycopene, and Prostate Cancer: Progress and Promise

12. Can the Consumption of Tomatoes or Lycopene Reduce Cancer Risk?

13. A Prospective Study of Tomato Products, Lycopene, and Prostate Cancer Risk

14. Lycopene and prostate cancer

15. Tomatoes, Tomato-Based Products, Lycopene, and Cancer: Review of the Epidemiologic Literature

16. Effects of Lycopene Supplementation in Patients with Localized Prostate Cancer

Stomach Cancer

1. Anticancer Effect of Lycopene in Gastric Carcinogenesis