Luteolin
Anti-cancer Activities
1. Luteolin and cancer metastasis suppression: focus on the role of epithelial to mesenchymal transition (2021)
2. Anticancer activity of the plant flavonoid luteolin against preclinical models of various cancers and insights on different signalling mechanisms modulated (2020)
3. Autophagy regulation using luteolin: new insight into its anti‑tumor activity (2020)
4. Luteolin mediated targeting of protein network and microRNAs in different cancers: Focus on JAK-STAT, NOTCH, mTOR and TRAIL-mediated signaling pathways (2020)
5. Luteolin, a flavonoid, as an anticancer agent: A review (2019)
6. Molecular targets of luteolin in cancer (2016)
7. Anti-carcinogenic Effects of the Flavonoid Luteolin (2008)
8. Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy (2008)
Bone Cancer
1. The flavonoid luteolin enhances doxorubicin-induced autophagy in human osteosarcoma U2OS cells
2. Molecular Mechanisms of Luteolin Induced Growth Inhibition and Apoptosis of Human Osteosarcoma Cells
Brain Cancer
1. Application of luteolin nanomicelles anti-glioma effect with improvement in vitro and in vivo
2. Luteolin reduces migration of human glioblastoma cell lines via inhibition of the p-IGF 1R/PI3K/AKT/mTOR signaling pathway
3. Biphasic effects of luteolin on interleukin-1β-induced cyclooxygenase-2 expression in glioblastoma cells
4. Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity
Breast Cancer
1. Luteolin inhibits lung metastasis, cell migration, and viability of triple-negative breast cancer cells
2. Luteolin Inhibits Breast Cancer Development and Progression In Vitro and In Vivo by Suppressing Notch Signaling and Regulating MiRNAs
3. Luteolin inhibits progestin‑dependent angiogenesis, stem cell‑like characteristics, and growth of human breast cancer xenografts
4. Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling Pathway
5. Synergistic apoptotic effect of celecoxib and luteolin on breast cancer cells
Colorectal Cancer
1. Combination of oncolytic adenovirus and luteolin exerts synergistic antitumor effects in colorectal cancer cells and a mouse model
2. Modulation of G2/M cell cycle arrest and apoptosis by luteolin in human colon cancer cells and xenografts
3. Luteolin, a Bioflavonoid Inhibits Colorectal Cancer through Modulation of Multiple Signaling Pathways: A Review
4. Cytotoxic Effect of Luteolin on Human Colorectal Cancer Cell Line (HCT-15): Crucial Involvement of Reactive Oxygen Species
5. Luteolin Induces Growth Arrest in Colon Cancer Cells Through Involvement of Wnt/β-Catenin/GSK-3βSignaling
Esophageal Cancer
1. Luteolin inhibits cell proliferation and induces cell apoptosis via down regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1and KYSE450
2. Luteolin Induced-growth Inhibition and Apoptosis of Human Esophageal Squamous Carcinoma Cell Line Eca109 Cells in vitro
Leukemia
1. Luteolin, a novel p90 ribosomal S6 kinase inhibitor, suppresses proliferation and migration in leukemia cells
Liver Cancer
In Vitro
1. Myocyte enhancer factor 2D promotes hepatocellular carcinoma through AMOTL2/YAP signaling that inhibited by luteolin (2022)
2. Targeted PD-L1 PLGA/liposomesmediated luteolin therapy for effective liver cancer cell treatment (2021)
3. Luteolin sensitizes human liver cancer cells to TRAIL induced apoptosis via autophagy and JNK mediated death receptor 5 upregulation (2019)
4. Regulation of apoptosis and autophagy by luteolin in human hepatocellular cancer Hep3B cells (2019)
5. Luteolin induces caspase-dependent apoptosis via inhibiting the AKT/osteopontin pathway in human hepatocellular carcinoma SK-Hep-1 cells (2018)
6. Luteolin and sorafenib combination kills human hepatocellular carcinoma cells through apoptosis potentiation and JNK activation (2018)
7. Luteolin Promotes Cell Apoptosis by Inducing Autophagy in Hepatocellular Carcinoma (2017)
8. Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF‑β pathway (2015)
9. The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation (2013)
10. Molecular mechanisms of luteolin-7-O-glucoside-induced growth inhibition on human liver cancer cells: G2/M cell cycle arrest and caspase-independent apoptotic signaling pathways (2013)
11. Anti-hepatoma cells function of luteolin through inducing apoptosis and cell cycle arrest (2013)
12. Reduction of Lipid Accumulation in HepG2 Cells by Luteolin is associated with Activation of AMPK and Mitigation of Oxidative Stress (2011)
13. Proteomic identification of anti-cancer proteins in luteolin-treated human hepatoma Huh-7 cells (2009)
14. Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K–Akt pathways (2006)
15. Increase of Bax/ Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line (2005)
16. Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK (2005)
In Vivo
1. Design and Optimization of Orally Administered Luteolin Nanoethosomes to Enhance Its Anti-Tumor Activity against Hepatocellular Carcinoma (2021)
2. The antitumour effect of galangin and luteolin with doxorubicin on chemically induced hepatocellular carcinoma in rats (2021)
3. Anticancer activity of the plant flavonoid luteolin against preclinical models of various cancers and insights on different signalling mechanisms modulated (2021)
4. Selective Cytotoxicity of Luteolin and Kaempferol on Cancerous Hepatocytes Obtained from Rat Model of Hepatocellular Carcinoma: Involvement of ROS-Mediated Mitochondrial Targeting (2018)
5. Modulatory effect of luteolin on redox homeostasis and inflammatory cytokines in a mouse model of liver cancer (2016)
6. Connexin 32 and luteolin play protective roles in nonalcoholic steatohepatitis development and its related hepatocarcinogenesis in rats (2015)
7. Effect of luteolin on gene expression in mouse H22 hepatoma cells (2015)
8. Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo (2014)
9. Evaluation of Luteolin in the Prevention of N-nitrosodiethylamine-induced Hepatocellular Carcinoma Using Animal Model System (2012)
10. Luteolin Promotes Degradation in Signal Transducer and Activator of Transcription 3 in Human Hepatoma Cells: An Implication for the Antitumor Potential of Flavonoids (2006)
Lung Cancer
1. Luteolin Inhibits Tumorigenesis and Induces Apoptosis of Non-Small Cell Lung Cancer Cells via Regulation of MicroRNA-34a-5p
2. Anticancer effect of luteolin is mediated by downregulation of TAM receptor tyrosine kinases, but not interleukin-8,in non-small cell lung cancer cells
3. Luteolin is effective in the non-small cell lung cancer model with L858R/T790MEGF receptor mutation and erlotinib resistance
Oral Cancer
1. Chemotherapeutic effects of luteolin on radio-sensitivity enhancement and interleukin-6/signal transducer and activator of transcription 3 signaling repression of oral cancer stem cells
Prostate Cancer
1. Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells
2. Luteolin inhibited proliferation and induced apoptosis of prostate cancer cells through miR-301
3. Gefitinib and Luteolin Cause Growth Arrest of Human Prostate Cancer PC-3 Cells via Inhibition of Cyclin G Associated Kinase and Induction of miR-630
4. Luteolin Inhibits Human Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2-Mediated Angiogenesis
5. Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin
Renal Cell Carcinoma
1. Induction of Apoptosis by Luteolin Involving Akt Inactivation in Human 786-O Renal Cell Carcinoma Cells
Skin Cancer
1. Luteolin Inhibits Protein Kinase Cε and c-Src Activities and UVB-Induced Skin Cancer
2. The Flavonoid Luteolin Increases the Resistance of Normal, but Not Malignant Keratinocytes, Against UVB-Induced Apoptosis
Stomach Cancer
1. Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 toSHP-1
2. Luteolin suppresses gastric cancer progression by reversing epithelial ‑mesenchymal transition via suppression of the Notch signaling pathway
3. Luteolin exerts a marked antitumor effect incMet-overexpressing patient-derived tumor xenograft models of gastric cancer
Thyroid Cancer
1. Luteolin suppresses tumor progression through lncRNA BANCR and its downstream TSHR/CCND1signaling in thyroid carcinoma
