Lung Cancer
Apigenin
1. Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependentmanner
2. Apigenin induces caspase-dependent apoptosis inhuman lung cancer A549 cells through Bax- andBcl-2-triggered mitochondrial pathway
3. Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer
Astragalus membranaceus
In Vitro
1. Astragalus Polysaccharide Suppresses Cell Proliferation and Invasion by Up-Regulation of miR-195-5p in Non-small Cell Lung Cancer (2022)
2. Astragaloside IV enhances the sensibility of lung adenocarcinoma cells to bevacizumab by inhibiting autophagy (2021)
3. Astragaloside IV sensitizes non-small cell lung cancer cells to cisplatin by suppressing endoplasmic reticulum stress and autophagy (2020)
4. Astragaloside IV Inhibits the Progression of Non-Small Cell Lung Cancer Through the Akt/GSK-3β/β-Catenin Pathway (2019)
5. Induction of Apoptosis by Ethyl Acetate Fraction of Astragalus membranaceus in Human Non-small Cell Lung Cancer Cells – Apoptosis Induction by Astragalus membranaceus – (2018)
6. Astragalus polysaccharide combined with 10-hydroxycamptothecin inhibits metastasis in non-small cell lung carcinoma cell lines via the MAP4K3/mTOR signaling pathway (2018)
7. Astragaloside IV sensitizes non–small cell lung cancer cells to gefitinib potentially via regulation of SIRT6 (2017)
8. Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3 (2016)
9. Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-α-ERK1/2-NF-κB pathway (2014)
10. Astragaloside IV increases MMP-2 mRNA and protein expression in human lung cancer A549 cells (2009)
In Vivo
1. Astragaloside IV and Saponins of Rhizoma Polygonati Cure Cyclophosphamide-Induced Myelosuppression in Lung Adenocarcinoma via Down-Regulating miR-142-3p (2021)
2. An Integrated Strategy for Effective-Component Discovery of Astragali Radix in the Treatment of Lung Cancer (2021)
3. Astragalus Polysaccharide (PG2) Suppresses Macrophage Migration Inhibitory Factor and Aggressiveness of Lung Adenocarcinoma Cells (2020)
4. Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer (2019)
5. The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function (2019)
6. Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling (2018)
7. Anticancer activity of Astragalus polysaccharide in human non‑small cell lung cancer cells (2017)
8. Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO (2014)
Clinical Trials
1. Effect of Astragalus Membranaceus on Patients with Metastatic Non-Small Cell Lung Cancer: A Retrospective Cohort Study (2021)
2. Astragalus-containing Chinese herbal combinations for advanced non-small-cell lung cancer: a meta-analysis of 65 clinical trials enrolling 4751 patients (2010)
3. Astragalus-Based Chinese Herbs and Platinum-Based Chemotherapy for Advanced Non–Small-Cell Lung Cancer: Meta-Analysis of Randomized Trials (2006)
Curcumin
In Vitro
1. Curcumin Inhibits Growth of Human NCI-H292 Lung Squamous Cell Carcinoma Cells by Increasing FOXA2 Expression
2. Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway
3. Curcumin induced autophagy anticancer effects on human lung adenocarcinoma cell line A549
4. Curcumin and Lung Cancer: the Role of microRNAs
5. Curcumin inhibits the development of non small cell lung cancer by inhibiting autophagy and apoptosis
6. Exploration of inhibitory mechanisms of curcumin in lung cancer metastasis using a miRNA- transcription factor-target gene network
7. Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction
8. Curcumin sensitizes human lung cancer cells to apoptosis and metastasis synergistically combined with carboplatin
9. Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway
10. Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway
11. Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1
12. Curcumin Induces Apoptosis of Upper Aerodigestive Tract Cancer Cells by Targeting Multiple Pathways
13. Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro
14. Potential anti-cancer effect of curcumin in human lung squamous cell carcinoma
15. Curcumin induces the apoptosis of non-small cell lung cancer cells through a calcium signaling pathway
16. Curcumin Blocks Small Cell Lung Cancer Cells Migration, Invasion, Angiogenesis, Cell Cycle and Neoplasia through Janus Kinase-STAT3 Signalling Pathway
17. The role of curcumin in response to BPDE-induced DNA damage in human lung epithelial cells.
18. Curcumin Induces Apoptosis in Human Non-small Cell Lung Cancer NCI-H460 Cells through ER Stress and Caspase Cascade- and Mitochondria-dependent Pathways
In Vivo
1.Curcumin inhibits human non-small cell lung cancer xenografts by targeting STAT3 pathway
2. Identification of curcumin-inhibited extracellular matrix receptors in non–small cell lung cancer A549 cells by RNA sequencing
3. Synergistic effect of fenretinide and curcumin for treatment of non-small cell lung cancer
4. Translating Curcumin to the Clinic for Lung Cancer Prevention: Evaluation of the Preclinical Evidence for Its Utility in Primary, Secondary, and Tertiary Prevention Strategies
5. Curcumin Lowers Erlotinib Resistance in Non-Small Cell Lung Carcinoma Cells With Mutated EGF Receptor
6. Study to Evaluate Molecular Mechanics behind Synergistic Chemo-Preventive Effects of Curcumin and Resveratrol during Lung Carcinogenesis
7. Curcumin: A Novel Stat 3 Pathway Inhibitor for Chemoprevention of Lung Cancer
8. Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer
9. Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of 1-antitrypsin in lung cancer
10. Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy
11. Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer
12. Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1
Honokiol
In Vitro
1. Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6-mediated matrix metalloproteinase 9 (2020)
2. Cytological effects of honokiol treatment and its potential mechanism of action in non-small cell lung cancer (2019)
3. Honokiol Inhibits Proliferation, Invasion and Induces Apoptosis Through Targeting Lyn Kinase in Human Lung Adenocarcinoma Cells (2018)
4. Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells (2017)
5. Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP (2016)
6. Honokiol from Magnolia spp. induces G1 arrest via disruption of EGFR stability through repressing HDAC6 deacetylated Hsp90 function in lung cancer cells (2015)
7. Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of -Catenin Signaling (2013)
8. Downregulation of Sp1 is involved in honokiol-inducedcell cycle arrest and apoptosis in human malignantpleural mesothelioma cells (2013)
In Vivo
1. Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity (2018)
2. Functional paclitaxel plus honokiol micelles destroying tumour metastasis in treatment of non-small-cell lung cancer (2018)
3. Honokiol Decreases Lung Cancer Metastasis through Inhibition of theSTAT3Signaling Pathway (2017)
4. Honokiol exhibits enhanced antitumor effects with chloroquine by inducing cell death and inhibiting autophagy in human non-small cell lung cancer cells (2015)
5. Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function (2014)
6. Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo (2013)
7. Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model (2008)
8. Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity (2008)
Isoflavones
1. Radioprotection of Lung Tissue by Soy Isoflavones
2. Soy Food Intake and Risk of Lung Cancer: Evidence From the Shanghai Women’s Health Study and a Meta-Analysis
3. Soy Isoflavones Radiosensitize Lung Cancer While Mitigating Normal Tissue Injury
4. Plasma Isoflavones and the Risk of Lung Cancer in Women: A Nested Case–Control Study in Japan
5. Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies
Luteolin
1. Luteolin Inhibits Tumorigenesis and Induces Apoptosis of Non-Small Cell Lung Cancer Cells via Regulation of MicroRNA-34a-5p
2. Anticancer effect of luteolin is mediated by downregulation of TAM receptor tyrosine kinases, but not interleukin-8,in non-small cell lung cancer cells
3. Luteolin is effective in the non-small cell lung cancer model with L858R/T790MEGF receptor mutation and erlotinib resistance
Lycopene
In Vitro
1. The effect of Lycopene as Immunotherapy and Immuno-modulatory in Lung Cancer, Tumor and Autoimmunity Treatment and Prevention
2. Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines
In Vivo
1. Can Smoke-Exposed Ferrets Be Utilized to Unravel the Mechanisms of Action of Lycopene?
2. Lycopene Supplementation Inhibits Lung Squamous Metaplasia and Induces Apoptosis via Up-Regulating Insulin-like Growth Factor-binding Protein 3 in Cigarette Smoke-exposed Ferrets
Clinical Trial
1. Tomato Lycopene and Lung Cancer Prevention: From Experimental to Human Studies
Panax ginseng
1. Bioactivity-guided isolation of ginsenosides from Korean red ginseng with cytotoxic activity against human lung adenocarcinoma cells
2. Ginsenoside from Panax ginseng Meyer Enhances the Cytotoxic and Apoptotic Effect of Cisplatin in A549 Human Lung Cancer Cells
3. Dammarane-type triterpene ginsenoside-Rg18 inhibits human non-small cell lung cancer A549 cell proliferation via G1 phase arrest
4. Modified Panax ginseng extract regulates autophagy by AMPK signaling in A549 human lung cancer cells
5. The antitumor activity study of ginsenosides and metabolites in lung cancer Cell
6. Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice
Probiotics
1. Role of probiotics in the management of lung cancer and related diseases: An Update
Resveratrol
In Vitro
1. Resveratrol raises in vitro anticancer effects of paclitaxel in NSCLC cell line A549 through CO X-2 expression
2. Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells
3. Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis
4. Resveratrol Enhances Etoposide-Induced Cytotoxicity through Down-Regulating ERK1/2 and AKT-Mediated X-ray Repair Cross-Complement Group 1 (XRCC1) Protein Expression in Human Non-Small-Cell Lung Cancer Cells
5. Anti-Inflammatory and Pro-apoptotic Effects of Curcumin and Resveratrol on the Human Lung Fibroblast Cell Line MRC-5
6. Resveratrol Modulates Expression of ABC Transporters in Non-Small Lung Cancer Cells: Molecular Docking and Gene Expression Studies
7. Resveratrol Induces Premature Senescence in Lung Cancer Cells via ROS-Mediated DNA Damage
8. Resveratrol Alters microRNA Expression Profiles in A549 Human Non-Small Cell Lung Cancer Cells
9. Molecular Mechanisms of Resveratrol Action in Lung Cancer Cells Using Dual Protein and Microarray Analyses
10. Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells
11. Resveratrol Enhances Radiosensitivity of Human Non-Small Cell Lung Cancer NCI-H838 Cells Accompanied by Inhibition of Nuclear Factor-Kappa B Activation
12.Resveratrol Induces Growth Inhibition, S-phase Arrest, Apoptosis, and Changes in Biomarker Expression in Several Human Cancer Cell Lines
In Vivo
1. Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies
2. Resveratrol in lung cancer- a systematic review
3. Study to Evaluate Molecular Mechanics behind Synergistic Chemo-Preventive Effects of Curcumin and Resveratrol during Lung Carcinogenesis
4. In vitro and in vivo Evaluation of the Antitumor Efficiency of Resveratrol Against Lung Cancer
5. Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[]pyrene
Vitamin C
1. High dose intravenous vitamin c treatment in a patient with lung cancer: A case Report
2. High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma
3. Association between vitamin C intake and lung cancer: a dose-response meta-analysis
