Honokiol

Anti-cancer Activities

Bladder Cancer

1. Pharmaceutical Evaluation of Honokiol and Magnolol on Apoptosis and Migration Inhibition in Human Bladder Cancer Cells (2020)

2. Honokiol Is a Potential Therapeutic Agent and Has a Synergistic Effect With 5-FU in Human Urothelial Cell Carcinoma Cells (2019)

3. Honokiol induces apoptotic cell death by oxidative burst and mitochondrial hyperpolarization of bladder cancer cells (2019)

4. Honokiol inhibits bladder cancer cell invasion through repressing SRC 3 expression and epithelial mesenchymal transition (2017)

5. Honokiol inhibits bladder tumor growth by suppressing EZH2/ miR-143 axis (2015)

Brain Cancer

In Vitro

1. Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma (2022)

2. Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells (2020)

3. Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway (2018)

4. Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and –tolerant glioma cells (2018)

5. Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration (2016)

6. Elimination of Cancer Stem-Like Cells and Potentiation of Temozolomide Sensitivity by Honokiol in Glioblastoma Multiforme Cells (2015)

7. Honokiol inhibits U87MG human glioblastoma cell invasion through endothelial cells by regulating membrane permeability and the epithelial-mesenchymal transition (2014)

8. The mechanism of honokiol-induced intracellular Ca2+ rises and apoptosis in human glioblastoma cells (2014)

9. Honokiol induced apoptosis and autophagy in glioblastoma multiforme cells (2013)

10. Honokiol exerts an anticancer effect in T98G human glioblastoma cells through the induction of apoptosis and the regulation of adhesion molecules (2012)

11. Honokiol-mediated Inhibition of PI3K/mTOR Pathway A Potential Strategy to Overcome Immunoresistance in Glioma, Breast, and Prostate Carcinoma Without Impacting T Cell Function (2009)

In Vivo

1. Liposomal honokiol inhibits glioblastoma growth through regulating macrophage polarization (2021)

2. Enhancing the anti-glioma therapy of doxorubicin by honokiol with biodegradable self-assembling micelles through multiple evaluations (2017)

3. Data analyses of honokiol-induced autophagy of human glioma cells in vitro and in vivo (2016)

4. Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway (2016)

5. Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis (2016)

6. Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas (2016)

7. Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrioncytochrome c-caspase protease pathway (2012)

8. Honokiol Crosses BBB and BCSFB, and Inhibits Brain Tumor Growth in Rat 9L Intracerebral Gliosarcoma Model and Human U251 Xenograft Glioma Model (2011)

Breast Cancer

In Vitro

1. Honokiol antagonizes doxorubicin resistance in human breast cancer via miR‑188‑5p/FBXW7/ c‑Myc pathway (2021)

2. Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon honokiol treatment (2020)

3. Honokiol inhibits the growth of SKBR3 cells (2020)

4. Enhancement in the Transdermal and Localized Delivery of Honokiol Through Breast Tissue (2018)

5. Concurrently suppressing multidrug resistance and metastasis of breast cancer by co-delivery of paclitaxel and honokiol with pH-sensitive polymeric micelles (2017)

6. Honokiol inhibits epithelialemesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis (2014)

7. Honokiol synergizes chemotherapy drugs in multidrug resistant breast cancer cells via enhanced apoptosis and additional programmed necrotic death (2013)

8. Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis (2012)

9. Honokiol, a phytochemical from Magnolia spp., inhibits breast cancer cell migration by targeting nitric oxide and cyclooxygenase-2 (2011)

10. Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells (2009)

In Vivo

1. Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth (2022)

2. Augment the efficacy of eradicating metastatic lesions and tumor proliferation in breast cancer by honokiol-loaded pH-sensitive targeted lipid nanoparticles (2021)

3. Design, Formulation and in vivo Evaluation of Novel Honokiol-Loaded PEGylated PLGA Nanocapsules for Treatment of Breast Cancer (2020)

4. Tuning mPEG-PLA/vitamin E-TPGS-based mixed micelles for combined celecoxib/honokiol therapy for breast cancer (2020)

5. Targeted delivery of honokiol by zein/hyaluronic acid core-shell nanoparticles to suppress breast cancer growth and metastasis (2020)

6. Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation (2019)

7. Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3 (2017)

8. Chemopreventive Activity of Honokiol against 7, 12-Dimethylbenz[a]anthracene-Induced Mammary Cancer in Female Sprague Dawley Rats (2017)

9. Biodegradable polymeric micelles coencapsulating paclitaxel and honokiol: a strategy for breast cancer therapy in vitro and in vivo (2017)

10. Honokiol sensitizes breast cancer cells to TNF-α induction of apoptosis by inhibiting Nur77 expression (2016)

11. Synergistic Antitumor Effects of Liposomal Honokiol Combined with Adriamycin in Breast Cancer Models (2008)

12. Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest (2007)

Effects of Honokiol on Colorectal Cancer

In Vitro

1. BMP7 mediates the anticancer effect of honokiol by upregulating p53 in HCT116 cells (2017)

2. Inferring the Effects of Honokiol on the Notch Signaling Pathway in SW480 Colon Cancer Cells (2014)

3. Expression of Survivin and p53 Modulates Honokiol-Induced Apoptosis in Colorectal Cancer Cells (2014)

4. Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells (2013)

5. Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects (2011)

In Vivo

1. Honokiol Affects Stem Cell Viability by Suppressing Oncogenic YAP1 Function to Inhibit Colon Tumorigenesis (2021)

2. Ultra-Performance Liquid Chromatography/Mass Spectrometry-Based Metabolomics for Discovering Potential Biomarkers and Metabolic Pathways of Colorectal Cancer in Mouse Model (ApcMin/+) and Revealing the Effect of Honokiol (2021)

3. Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity (2021)

4. Anti‑proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF‑β1/p53 signaling pathway (2020)

5. Honokiol in combination with radiation targets Notch signaling to inhibit colon cancer stem cells (2012)

6. Synergistic antitumor effects of liposomal honokiol combined with cisplatin in colon cancer models (2011)

7. Honokiol: A potent chemotherapy candidate for human colorectal Carcinoma (2004)

Leukemia

In Vitro

1. Honokiol induces paraptosis‑like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation (2021)

2. Honokiol Inhibits Constitutive and Inducible STAT3 Signaling via PU.1-Induced SHP1 Expression in Acute Myeloid Leukemia Cells (2015)

3. Honokiol induces caspase-independent paraptosis via reactive oxygen species production that is accompanied by apoptosis in leukemia cells (2013)

4. The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells (2005)

5. Magnolol and honokiol enhance HL-60 human leukemia cell differentiation induced by 1,25-dihydroxyvitamin D3 and retinoic acid (2005)

In Vivo

1. Honokiol-Chlorambucil Co-Prodrugs Selectively Enhance the Killing Effect through STAT3 Binding on Lymphocytic Leukemia Cells In Vitro and In Vivo (2020)

2. Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia (2017)

3. Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia (2012)

Liver Cancer

In Vitro

1. Honokiol inhibits hepatoma carcinoma cell migration through downregulated Cyclophilin B expression (2021)

2. The inhibition effect of Honokiol in liver cancer (2018)

3. Combined effect of honokiol and rosiglitazone on cell growth inhibition through enhanced G0/G1 phase arrest in hepatoma cells (2016)

4. KRT6B, a key mediator of notch signaling in honokiol-induced human hepatoma cell apoptosis (2015)

5. Growth Inhibitory Activity of Honokiol through Cell-cycle Arrest, Apoptosis and Suppression of Akt/mTOR Signaling in Human Hepatocellular Carcinoma Cells (2013)

6. Honokiol Inhibits Signal Transducer and Activator of Transcription-3 Signaling, Proliferation, and Survival of Hepatocellular Carcinoma Cells Via the Protein Tyrosine Phosphatase SHP-1 (2012)

7. Reactive oxygen species production and Bax/Bcl-2 regulation in honokiol-induced apoptosis in human hepatocellular carcinoma SMMC-7721 cells (2009)

In Vivo

1. Honokiol Acts as a Potent Anti-Fibrotic Agent in the Liver through Inhibition of TGF-β1/SMAD Signaling and Autophagy in Hepatic Stellate Cells (2021)

2. Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor—MIG6 Axis (2021)

3. Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways (2017)

Lung Cancer

In Vitro

1. Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6-mediated matrix metalloproteinase 9 (2020)

2. Cytological effects of honokiol treatment and its potential mechanism of action in non-small cell lung cancer (2019)

3. Honokiol Inhibits Proliferation, Invasion and Induces Apoptosis Through Targeting Lyn Kinase in Human Lung Adenocarcinoma Cells (2018)

4. Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells (2017)

5. Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP (2016)

6. Honokiol from Magnolia spp. induces G1 arrest via disruption of EGFR stability through repressing HDAC6 deacetylated Hsp90 function in lung cancer cells (2015)

7. Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of -Catenin Signaling (2013)

8. Downregulation of Sp1 is involved in honokiol-inducedcell cycle arrest and apoptosis in human malignantpleural mesothelioma cells (2013)

In Vivo

1. Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity (2018)

2. Functional paclitaxel plus honokiol micelles destroying tumour metastasis in treatment of non-small-cell lung cancer (2018)

3. Honokiol Decreases Lung Cancer Metastasis through Inhibition of theSTAT3Signaling Pathway (2017)

4. Honokiol exhibits enhanced antitumor effects with chloroquine by inducing cell death and inhibiting autophagy in human non-small cell lung cancer cells (2015)

5. Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function (2014)

6. Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo (2013)

7. Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model (2008)

8. Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity (2008)

Effects of Honokiol on Oral Cancer

In Vitro

1. Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor-b/Smad2/3 signaling inhibition (2021)

2. Chemosensitizing effect of honokiol in oral carcinoma stem cells via regulation of IL-6/Stat3 signaling (2018)

3. Anti-proliferative effect of honokiol in oral squamous cancerthrough the regulation of specificity protein 1 (2013)

4. Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/-Catenin Signaling and Apoptosis Induction (2013)

5. Honokiol: a promising small molecular weight natural agent for the growth inhibition of oral squamous cell carcinoma cells (2011)

In Vivo

1. SYNERGISTIC THERAPEUTIC EFFECT OF HONOKIOL AND 5-FLUOROURACIL ON THE INDUCED-TONGUE CANCER IN RATS (2021)

2. Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement Magnolia officinalis Extract for Prevention against Oral Carcinoma (2020)

3. Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I (2020)

4. Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy (2018)

5. Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction (2016)

6. Synergistic effect of honokiol and 5-fluorouracil on apoptosis of oral squamous cell carcinoma cells (2016)

7. Multifunctional effects of honokiol as an anti-inflammatory and anticancer drug in human oral squamous cancer cells and xenograft (2015)

Osetosarcoma

1. Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo (2018)

2. Honokiol induces autophagy and apoptosis of osteosarcoma through PI3K/Akt/mTOR signaling pathway (2018)

3. Honokiol suppresses proliferation and induces apoptosis via regulation of the miR‑21/PTEN/ PI3K/AKT signaling pathway in human osteosarcoma cells (2018)

4. Antimetastatic Activity of Honokiol in Osteosarcoma (2012)

Ovarian Cancer

1. Honokiol induces apoptosis and suppresses migration and invasion of ovarian carcinoma cells via AMPK/mTOR signaling pathway (2019)

2. Improving therapeutic effect in ovarian peritoneal carcinomatosis with honokiol nanoparticles in a thermosensitive hydrogel composite (2012)

3. Liposomal honokiol, a promising agent for treatment of cisplatin-resistant human ovarian cancer (2008)

4. Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells (2008)

Pancreatic Cancer

1. Honokiol Suppresses Perineural Invasion of Pancreatic Cancer by Inhibiting SMAD2/3 Signaling (2021)

2. Honokiol Suppressed Pancreatic Cancer Progression via miR-101/Mcl-1 Axis (2020)

3. Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor–stromal cross-talk (2016)

4. Honokiol Arrests Cell Cycle, Induces Apoptosis, and Potentiates the Cytotoxic Effect of Gemcitabine in Human Pancreatic Cancer Cells (2011)

Prostate Cancer

In Vitro

1. c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells (2016)

2. Honokiol Inhibits Androgen Receptor Activity in Prostate Cancer Cells (2014)

3. HonokiolActivates ReactiveOxygen Species-Mediated CytoprotectiveAutophagy inHuman ProstateCancerCells (2014)

4. Honokiol-mediated Inhibition of PI3K/mTOR Pathway A Potential Strategy to Overcome Immunoresistance in Glioma, Breast, and Prostate Carcinoma Without Impacting T Cell Function(2009)

5. Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity (2007)

In Vivo

1. Honokiol, a Natural Plant Product, Inhibits the Bone Metastatic Growth of Human Prostate Cancer Cells (2007)

Renal Cell Carcinoma

In Vitro

1. Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells (2020)

2. A Novel Combination Treatment with Honokiol and Rapamycin Effectively Restricts c-Met-Induced Growth of Renal Cancer Cells, and also Inhibits the Expression of Tumor Cell PD-L1 Involved in Immune Escape (2020)

3. Honokiol, a Polyphenol Natural Compound, Attenuates Cisplatin-Induced Acute Cytotoxicity in Renal Epithelial Cells Through Cellular Oxidative Stress and Cytoskeleton Modulations (2018)

4. Honokiol inhibits migration of renal cell carcinoma through activation of RhoA/ROCK/MLC signaling pathway (2016)

5. Honokiol suppresses metastasis of renal cell carcinoma by targeting KISS1/KISS1R signaling (2015)

In Vivo

1. Honokiol inhibits c-Met-HO-1 tumor-promoting pathway and its cross-talk with calcineurin inhibitormediated renal cancer growth (2017)

2. Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling (2014)

Effects of Honokiol on Skin Cancer

In Vitro

1. Green Synthesized Honokiol Transfersomes Relieve the Immunosuppressive and Stem-Like Cell Characteristics of the Aggressive B16F10 Melanoma (2021)

2. Honokiol Inhibits Melanoma Stem Cells by Targeting Notch Signaling (2015)

3. Honokiol affects melanoma cell growth by targeting the AMPK signaling pathway (2014)

4. Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells (2012)

5. Honokiol, a chemopreventive agent against skin cancer, induces cell cycle arrest and apoptosis in human epidermoid A431 cells (2011)

6. Honokiol Produces Anti-Neoplastic Effects on Melanoma Cells In Vitro (2011)

In Vivo

1. Honokiol Inhibits Melanoma Growth by Targeting Keratin 18 in vitro and in vivo (2020)

2. Antineoplastic Effects of Honokiol on Melanoma (2017)

3. Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells (2016)

4. Chemopreventive effects of combination of honokiol and magnolol with α-santalol on skin cancer developments (2013)

5. Time and dose-response effects of honokiol on UVB-induced skin cancer development (2012)

6. Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation (2010)

7. Chemopreventive Effects of Honokiol on UVB-induced Skin Cancer Development (2010)

Stomach Cancer

In Vitro

1. Honokiol Suppression of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastric Cancer Cell Biological Activity and Its Mechanism (2020)

2. Honokiol induces cell cycle arrest and apoptosis in human gastric carcinoma MGC-803 cell line (2015)

3. G0/G1 Cell Cycle Arrest and Activation of Caspases in Honokiol-mediated Growth Inhibition of Human Gastric Cancer Cells (2012)

In Vivo

1. Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-tomesenchymal transition (2015)

2. Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model (2013)

3. Calpain/SHP-1 Interaction by Honokiol Dampening Peritoneal Dissemination of Gastric Cancer in nu/nu Mice (2012)

4. Honokiol Induces Calpain-Mediated Glucose-Regulated Protein-94 Cleavage and Apoptosis in Human Gastric Cancer Cells and Reduces Tumor Growth (2007)