Green Tea

Anti-cancer Activities

1. The Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review (2022)

2. Green Tea Catechins: Nature’sWay of Preventing and Treating Cancer (2022)

3. Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer (2020)

4. Molecular Targets of Epigallocatechin—Gallate (EGCG): A Special Focus on Signal Transduction and Cancer (2018)

5. Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea (2018)

6. Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells (2018)

7. Biophysical Approach to Mechanisms of Cancer Prevention and Treatment with Green Tea Catechins (2016)

8. Green tea mechanism of action in fighting different types of cancer (2015)

9. Anticancer effects and molecular mechanisms of epigallocatechin-3-gallate (2014)

10. Going Green: The Role of the Green Tea Component EGCG in Chemoprevention (2013)

11. Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer Therapy (2013)

12. Cancer prevention by green tea: evidence from epidemiologic studies (2013)

13. Green tea and green tea catechin extracts: An overview of the clinical evidence (2012)

14. Cancer and metastasis: prevention and treatment by green tea (2010)

15. Reading the Tea Leaves: Anticarcinogenic Properties of (-)-Epigallocatechin-3-Gallate (2007)

16. Cancer Preventive Mechanisms of the Green Tea Polyphenol (-)-Epigallocatechin-3-gallate (2007)

Bladder Cancer

Brain Cancer

In Vitro

1. Achievable Central Nervous System Concentrations of the Green Tea Catechin EGCG Induce Stress in Glioblastoma Cells in Vitro (2018)

2. Epigallocatechin-3-gallate induces apoptosis and proliferation inhibition of glioma cell through suppressing JAK2/STAT3 signaling pathway (2016)

3. Tocotrienol-Rich Fraction, [6]-Gingerol and Epigallocatechin Gallate Inhibit Proliferation and Induce Apoptosis of Glioma Cancer Cells (2014)

4. Epigallocatechin-3-gallate induces apoptosis, inhibits proliferation and decreases invasion of glioma cell (2014)

5. EGCG inhibits properties of glioma stem-like cells and synergizes with temozolomide through downregulation of P-glycoprotein inhibition (2014)

6. The sensitization of glioma cells to cisplatin and tamoxifen by the use of catechin (2009)

7. Epigalocatechin-3-gallate (EGCG) downregulates PEA15 and thereby augments TRAIL-mediated apoptosis in malignant glioma (2008)

8. Green tea extract, epigallocatechin-3-gallate, inhibits the growth and invasive ability of human glioma cells (2008)

9. Epigallocatechin-3-gallate exhibits anti-tumor effect by perturbing redox homeostasis, modulating the release of pro-inflammatory mediators and decreasing the invasiveness of glioblastoma cells (2008)

10. The Survivin-mediated radioresistant phenotype of glioblastomas is regulated by RhoA and inhibited by the green tea polyphenol (−)-epigallocatechin-3-gallate (2006)

11. Combined low dose ionizing radiation and green tea-derived epigallocatechin-3-gallate treatment induces human brain endothelial cells death (2006)

12. Probing the infiltrating character of brain tumors: inhibition of RhoA/ROK-mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCG (2005)

13. Green tea polyphenol (3)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells (2002)

14. Green tea compounds inhibit tyrosine phosphorylation of PDGF L-receptor and transformation of A172 human glioblastoma (2000)

15. Inhibitory effect of epigallocatechin-gallate on brain tumor cell lines in vitro (2000)

In Vivo

1. A Tumor-Specific Ferric-Coordinated Epigallocatechin-3-gallate cascade nanoreactor for glioblastoma therapy (2021)

2. Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models (2011)

Clinical Trials

1. A prospective study of coffee and tea consumption and the risk of glioma in the UK Biobank (2020)

2. Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study (2010)

Meta-analysis and Review

1. Coffee and tea consumption and the risk of glioma: a systematic review and dose–response meta-analysis (2022)

2. A prospective study of tea and coffee intake and risk of glioma (2020)

3. Effects of the Green Tea Polyphenol Epigallocatechin-3-Gallate on Glioma: A Critical Evaluation of the Literature (2018)

Breast Cancer

In Vitro

1. EGCG Prevents the Onset of an Inflammatory and Cancer-Associated Adipocyte-like Phenotype in Adipose-Derived Mesenchymal Stem/Stromal Cells in Response to the Triple-Negative Breast Cancer Secretome (2022)

2. Role of epigallocatechin-3-gallate in the regulation of known and novel microRNAs in breast carcinoma cells (2022)

3. EGCG Inhibits Adipose-Derived Mesenchymal Stem Cells Differentiation into Adipocytes and Prevents a STAT3-Mediated Paracrine Oncogenic Control of Triple-Negative Breast Cancer Cell Invasive Phenotype (2021)

4. Green Tea (Camellia sinensis) Extract Induces p53-Mediated Cytotoxicity and Inhibits Migration of Breast Cancer Cells (2021)

5. Green Tea Catechins Induce Inhibition of PTP1B Phosphatase in Breast Cancer Cells with Potent Anti-Cancer Properties: In Vitro Assay, Molecular Docking, and Dynamics Studies (2020)

6. Assessment Synergistic Effects of Integrated Therapy with Epigallocatechin-3-Gallate (EGCG) & Arsenic Trioxide and Irradiation on Breast Cancer Cell Line (2020)

7. Anti-neoplastic effect of epigallocatechin gallate on breast cancer cells through glucose metabolism (2019)

8. Bioinformatics analysis of microarray profiling identifies the mechanism of focal adhesion kinase signalling pathway in proliferation and apoptosis of breast cancer cells modulated by green tea polyphenol epigallocatechin 3-gallate (2018)

9. Epigallocatechin gallate inhibits the growth of MDA MB 231 breast cancer cells via inactivation of the β catenin signaling pathway (2017)

10. Estrogen receptor-a36 is involved in epigallocatechin-3-gallate induced growth inhibition of ER-negative breast cancer stem/progenitor cells (2016)

11. Epigallocatechin gallate enhances 5-fluorouracil antitumor activity in MCF7 cells by regulating the expression of Bcl-xL (2016)

12. Potentiation of growth inhibition and epigenetic modulation by combination of green tea polyphenol and 5-aza-2’-deoxycytidine in human breast cancer cells (2015)

13. Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells (2014)

14. Epigenetic Induction of Tissue Inhibitor of Matrix Metalloproteinase-3 by Green Tea Polyphenols in Breast Cancer Cells (2014)

15. Epigallocatechin gallate induces the steady state mRNA levels of pS2 and PR genes in MCF-7 breast cancer cells (2014)

16. Anticancer activities of (-)-epigallocatechin-3-gallate encapsulated nanoliposomes in MCF7 breast cancer cells (2013)

17. In vitro mechanism for downregulation of ER-α expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells (2013)

18. Tea Polyphenols Modulate Antioxidant Redox System on Cisplatin-induced Reactive Oxygen Species Generation in a Human Breast Cancer Cell (2013)

19. Green Tea Catechin Extract in Intervention of Chronic Breast Cell Carcinogenesis Induced by Environmental Carcinogens (2012)

20. A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells (2011)

21. (–)-Epigallocatechin-3-gallate down-regulates EGFR, MMP-2, MMP-9 and EMMPRIN and inhibits the invasion of MCF-7 tamoxifen-resistant cells (2011)

22. Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced a9-nicotinic acetylcholine receptor upregulation in human breast cancer cells (2011)

23. Epigallocatechin-3-gallate (EGCG) downregulates EGF-induced MMP-9 in breast cancer cells: involvement of integrin receptor α5β1 in the process (2011)

24. Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells (2010)

25. Inhibition of catechol-O-methyltransferase activity in human breast cancer cells enhances the biological effect of the green tea polyphenol (-)-EGCG (2010)

26. In vitro mechanism of action for the cytotoxicity elicited by the combination of epigallocatechin gallate and raloxifene in MDA-MB-231 cells (2010)

27. (-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line (2010)

28. Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7 (2009)

29. Green tea (−)-epigallocatechin-3-gallate down-regulates VASP expression and inhibits breast cancer cell migration and invasion by attenuating Rac1 activity (2009)

30. Epigenetic and Genetic Mechanisms Contribute to Telomerase Inhibition by EGCG (2008)

31. Epigallocatechin-3 gallate induces growth inhibition and apoptosis in human breast cancer cells through survivin suppression (2007)

32. Activation of FOXO3a by the Green Tea Polyphenol Epigallocatechin-3-Gallate Induces Estrogen Receptor A Expression Reversing Invasive Phenotype of Breast Cancer Cells (2007)

33. Trastuzumab-Resistant HER2-Driven Breast Cancer Cells Are Sensitive to Epigallocatechin-3 Gallate(2007)

34. (-)-Epigallocatechin-3-gallate downregulates estrogen receptor alpha function in MCF-7 breast carcinoma cells (2007)

35. Tea Polyphenol (-)-Epigallocatechin 3-Gallate Suppresses Heregulin-β1-Induced Fatty Acid Synthase Expression in Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase/Akt and Mitogen-Activated Protein Kinase Cascade Signaling (2007)

36. Epigallocatechin Gallate Dose-Dependently Induces Apoptosis or Necrosis in Human MCF-7 Cells (2007)

37. The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells (2006)

38. Microarray-Assisted Pathway Analysis Identifies Mitogen-Activated Protein Kinase Signaling as a Mediator of Resistance to the Green Tea Polyphenol Epigallocatechin 3-Gallate in Her-2/neu–Overexpressing Breast Cancer Cells (2006)

39. Green Tea Polyphenols Modulate Secretion of Urokinase Plasminogen Activator (uPA) and Inhibit Invasive Behavior of Breast Cancer Cells (2005)

40. Tamoxifen and epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells (2004)

41. Screening of Chemopreventive Tea Polyphenols Against PAH Genotoxicity in Breast Cancer Cells by a XRE-Luciferase Reporter Construct (2003)

42. Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects (2003)

In Vivo

1. Tea Polyphenol Epigallocatechin-3-Gallate Inhibits Cell Proliferation In a Patient-Derived Triple-Negative Breast Cancer Xenograft Mouse Model Via Inhibition of Proline-Dehydrogenase-Induced Effects (2021)

2. Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models (2018)

3. Epigallocatechin-3-Gallate Inhibits Stem-Like Inflammatory Breast Cancer Cells (2013)

4. Prevention of Mammary Carcinogenesis in C3H/OuJ Mice by Green Tea and Tamoxifen (2011)

5. (-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma (2010)

6. Breast Cancer Prevention by Green Tea Catechins and Black Tea Theaflavins in the C3(1) SV40 T,t Antigen Transgenic Mouse Model Is Accompanied by Increased Apoptosis and a Decrease in Oxidative DNA Adducts (2007)

7. Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo (2007)

8. The combination of green tea and tamoxifen is effective against breast cancer (2006)

9. Growth Inhibitory and Antimetastatic Effect of Green Tea Polyphenols on Metastasis-Specific Mouse Mammary Carcinoma 4T1 Cells In vitro and In vivo Systems (2005)

10. Green Tea Extracts Decrease Carcinogen-Induced Mammary Tumor Burden in Rats and Rate of Breast Cancer Cell Proliferation in Culture (2001)

Clinical Trials

1. Phase IB Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with Hormone Receptor–Negative Breast Cancer (2012)

2. Anti-Cancer Activities of Tea Epigallocatechin-3-Gallate in Breast Cancer Patients under Radiotherapy (2012)

3. Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study (2008)

Systematic Review and Review

1. Protective Effects of Epigallocatechin Gallate (EGCG) on Endometrial, Breast, and Ovarian Cancers (2020)

2. Interaction of Green Tea Catechins with Breast Cancer Endocrine Treatment: A Systematic Review (2014)

3. Effect of green tea catechins on breast carcinogenesis: a systematic review of in-vitro and in-vivo experimental studies (2014)

4. Green Tea Catechins: Proposed Mechanisms of Action in Breast Cancer Focusing on the Interplay Between Survival and Apoptosis (2014)

5. Green tea compounds in breast cancer prevention and Treatment (2014)

Cervical Cancer

In Vitro

1. Suppressing effects of green tea extract and Epigallocatechin-3-gallate (EGCG) on TGF-β- induced Epithelial-to-mesenchymal transition via ROS/ Smad signaling in human cervical cancer cells (2021)

2. Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways (2020)

3. Enoxacin and Epigallocatechin Gallate (EGCG) Act Synergistically to Inhibit the Growth of Cervical Cancer Cells in Culture (2019)

4. Epigallocatechin gallate inhibits cell growth and regulates miRNA expression in cervical carcinoma cell lines infected with different high risk human papillomavirus subtypes (2019)

5. Epigallocatechin gallate in combination with eugenol or amarogentin shows synergistic chemotherapeutic potential in cervical cancer cell line (2018)

6. Comparative efficacy of epigallocatechin-3-gallate against H2O2-induced ROS in cervical cancer biopsies and HeLa cell lines (2017)

7. Synergistic anticancer activity of dietary tea polyphenols and bleomycin hydrochloride in human cervical cancer cell: Caspase dependent and independent apoptotic pathways (2016)

8. Epigallocatechin-3-gallate shows anti-proliferative activity in HeLa cells targeting tubulin-microtubule equilibrium (2015)

9. EGCG suppresses Fused Toes Homolog protein through p53 in cervical cancer cells (2013)

10. Early transcriptional pattern of angiogenesis induced by EGCG treatment in cervical tumour cells (2012)

11. (-)-Epigallocatechin-3-Gallate Induces Apoptosis and Inhibits Invasion and Migration of Human Cervical Cancer Cells (2012)

12. Tea Polyphenols Induce Apoptosis Through Mitochondrial Pathway and by Inhibiting Nuclear Factor-B and Akt Activation in Human Cervical Cancer Cells (2011)

13. Green Tea Compound in Chemoprevention of Cervical Cancer (2010)

14. Apoptotic Effect of Green Tea Polyphenol (EGCG) on Cervical Carcinoma Cells (2010)

15. Cell Growth Inhibition and Gene Expression Regulation by (-)-Epigallocatechin-3-Gallate in Human Cervical Cancer Cells (2009)

16. Antiproliferative effects of the major tea polyphenol, (−)-epigallocatechin gallate and retinoic acid in cervical adenocarcinoma (2008)

17. Inhibitory effect of the tea polyphenol, (-)-epigallocatechin gallate, on growth of cervical adenocarcinoma cell lines (2006)

18. Epigallocatechin-3-gallate Inhibits Epidermal Growth Factor Receptor Signaling Pathway (2004)

19. The tea polyphenol, (−)-epigallocatechin gallate effects on growth, apoptosis, and telomerase activity in cervical cell lines (2004)

In Vivo

1. Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa celltumor xenografts in female nude mice (2015)

2. A Major Constituent of Green Tea, EGCG, Inhibits the Growth of a Human Cervical Cancer Cell Line, CaSki Cells, through Apoptosis, G1 Arrest, and Regulation of Gene Expression (2003)

Clinical Trials

1. Case-Control Study of Diet in Patients with Cervical Cancer or Precancerosis in Wufeng, a High Incidence Region in China (2012)

2. Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions (2003)

Review

1. Green Tea Epigallocatechin-3-Gallate Regulates Autophagy in Male and Female Reproductive Cancer (2022)

2. Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer (2020)

3. Suppressive Effects of EGCG on Cervical Cancer (2018)

4. Epigallocatechin-3-Gallate (EGCG): mechanisms, perspectives and clinical applications in cervical cancer (2018)

Cholangiocarcinoma

1. Tea consumption and the risk of biliary tract cancer: a systematic review and dose–response meta-analysis of observational studies (2017)

2. Anticancer activities of epigallocatechin-3-gallate against cholangiocarcinoma cells (2017)

3. The green tea catechin epigallocatechin gallate induces cell cycle arrest and shows potential synergism with cisplatin in biliary tract cancer cells(2015)

4. Synergistic Anticancer Effects of Vorinostat and Epigallocatechin-3-Gallate against HuCC-T1 Human Cholangiocarcinoma Cells (2013)

5. Quercetin and EGCG Exhibit Chemopreventive Effects in Cholangiocarcinoma Cells via Suppression of JAK/STAT Signaling Pathway (2013)

6. Epigallocatechin-gallatemodulates chemotherapy-induced apoptosis in human cholangiocarcinoma cells (2009)

7. Prevention of dual promoting effects of pentachlorophenol, an environmental pollutant, on diethylnitrosamine-induced hepato- and cholangiocarcinogenesis in mice by green tea infusion (2003)

Colorectal Cancer

In Vitro

1. (-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/-Catenin Pathway

2. The synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cells

3. Green Tea Polyphenol Epigallocatechin 3-Gallate, Contributes to the Degradation of DNMT3A and HDAC3 in HCT 116 Human Colon Cancer Cells

4. (-)-Epigallocatechin-3-gallate suppresses liver metastasis of human colorectal cancer

5. Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea

6. (-)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells

7. EGCG synergizes the therapeutic effect of cisplatin and oxaliplatin through autophagic pathway in human colorectal cancer cells

8. (–)-Epigallocatechin-3-Gallate (EGCG) Post-transcriptionally and Post-translationally Suppresses the Cell Proliferative Protein TROP2 in Human Colorectal Cancer Cells

9. Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells

In Vivo

1. Structural shift of gut microbiota during chemopreventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice

2. Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer

3. Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling

4. (−)-Epigallocatechin Gallate Suppresses Azoxymethane-Induced Colonic Premalignant Lesions in Male C57BL/KsJ-db/db Mice

5. Protective Effects of Epigallocatechin Gallate on Colon Preneoplastic Lesions Induced by 2-Amino-3-Methylimidazo[4,5-f ]Quinoline in Mice

Clinical Trials

1. Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells

2. Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies

3. Protocol for Minimizing the Risk of Metachronous Adenomas of the Colorectum with Green Tea Extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population

4. Prospective Cohort Study of Green Tea Consumption and Colorectal Cancer Risk in Women

5. Ingestion of Green Tea Rapidly Decreases Prostaglandin E2 Levels in Rectal Mucosa in Humans

Esophageal Cancer

In Vitro

1. Carboplatin and epigallocatechin-3-gallate synergistically induce cytotoxic effects in esophageal cancer cells (2021)

2. Epigallocatechin 3 gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells (2017)

3. Epigallocatechin-3-gallate inhibits growth and induces apoptosis in esophageal cancer cells through the demethylation and reactivation of the p16 gene (2017)

4. Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells (2017)

5. Enhancement of (-)-epigallocatechin-3-gallate and theaflavin-3-3’-digallate induced apoptosis by ascorbic acid in human lung adenocarcinoma SPC-A-1 cells and esophageal carcinoma Eca-109 cells via MAPK pathways (2013)

6. Polyphenon E Inhibits the Growth of Human Barrett’s and Aerodigestive Adenocarcinoma Cells by Suppressing Cyclin D1 Expression (2009)

7. Mechanism of Action of (-)-Epigallocatechin-3-Gallate: Auto-oxidation–Dependent Inactivation of Epidermal Growth Factor Receptor and Direct Effects on Growth Inhibition in Human Esophageal Cancer KYSE 150 Cells (2005)

In Vivo

1. Molecular mechanism of epigallocatechin-3-gallate in human esophageal squamous cell carcinoma in vitro and in vivo (2015)

2. Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin (2012)

3. Inhibitory effects of epigallocatechin-3-gallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats (2002)

4. Inhibition of TV-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by green and black tea (1995)

Clinical Trials

1. Influence of Tea Consumption on the Development of Second Esophageal Neoplasm in Patients with Head and Neck Cancer (2019)

2. Phase II Trial of Epigallocatechin-3-Gallate in Acute Radiation-Induced Esophagitis for Esophagus Cancer (2019)

3. Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett’s Esophagus (2015)

4. Prospective cohort study of tea consumption and risk of digestive system cancers: results from the Shanghai Women’s Health Study (2012)

Meta-analysis & Review

1. Green Tea Consumption and Esophageal Cancer Risk: A Meta-analysis (2019)

2. Inhibitory Effects of (-)-Epigallocatechin-3-gallate on Esophageal Cancer (2019)

3. Effects of Green Tea, Black Tea, and Coffee Consumption on the Risk of Esophageal Cancer: A Systematic Review and Meta-Analysis of Observational Studies (2013)

4. Green tea and prevention of esophageal and lung cancers (2011)

Leukemia

In Vitro

1. A comparative study of anti-leukemic effects of kaempferol and epigallocatechin-3-gallate (EGCG) on human leukemia HL-60 cells (2021)

2. The Impact of EGCG and RG108 on SOCS1 Promoter DNA Methylation and Expression in U937 Leukemia Cells (2021)

3. The oxidation of (-)-epigallocatechin-3-gallate inhibits T-cell acute lymphoblastic leukemia cell line HPB-ALL via the regulation of Notch1 expression (2020)

4. Combined effect of (‑)‑epigallocatechin‑3‑gallate and all‑trans retinoic acid in FLT3‑mutated cell lines (2020)

5. Effects of green tea epigallocatechin-3-gallate on transcription factors regulating expression of FLT3 (2020)

6. Involvement of pRb-E2F pathway in green tea extract-induced growth inhibition of human myeloid leukemia cells (2019)

7. (−)‐Epigallocatechin‐3‐gallate induces cell apoptosis in chronic myeloid leukaemia by regulating Bcr/Abl‐mediated p38‐MAPK/JNK and JAK2/STAT3/AKT signalling pathways (2019)

8. Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells (2018)

9. The Inhibitory Effect of Epigallocatechin Gallate on the Viability of T Lymphoblastic Leukemia Cells is Associated with Increase of Caspase-3 Level and Fas Expression (2018)

10. Epigallocatechin‐3‐gallate enhances differentiation of acute promyelocytic leukemia cells via inhibition of PML‐RARα and HDAC1 (2017)

11. Epigallocatechin 3 gallate induces apoptosis in acute promyelocytic leukemia cells via a SHP 1 p38α MAPK Bax cascade (2017)

12. Green tea polyphenol “epigallocatechin-3-gallate”, differentially induces apoptosis in CLL B-and T-Cells but not in healthy B-and T-Cells in a dose dependant manner (2016)

13. Epigallocatechingallate, ellagicacid, and rosmarinic acid perturbdNTP pools and inhibit denovo DNA synthesis and proliferation of human HL60 promyelocytic leukemiacells: Synergism with arabinofuranosylcytosine (2015)

14. Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells (2015)

15. Transcriptional targeting of sphingosine-1- phosphate receptor S1P2 by epigallocatechin- 3-gallate prevents sphingosine-1-phosphate-mediated signaling in macrophage-differentiated HL-60 promyelomonocytic leukemia cells (2014)

16. Synergistic effect of ponatinib and epigallocatechin-3-gallate induces apoptosis in chronic myeloid leukemia cells through altering expressions of cell cycle regulatory genes (2014)

17. Epigallocatechin-3-gallate Inhibits Tax-dependent Activation of Nuclear Factor Kappa B and of Matrix Metalloproteinase 9 in Human T-cell Lymphotropic Virus-1 Positive Leukemia Cells (2014)

18. Inhibition of FLT3 Expression by Green Tea Catechins in FLT3 Mutated-AML Cells (2013)

19. EGCG targeting efficacy of NF-B downstream gene products is dictated by the monocytic/macrophagic differentiation status of promyelocytic leukemia cells (2012)

20. Green Tea Extract EGCG Induces Apoptosis in CLL Cells and Overcomes the Supportive Effect of Primary Bone Marrow Stromal Cells Through the Regulation of PI3K/Akt Cascade and Proteasome Activity (2012)

21. (-)-Epigallocatechin-3-O-gallate Induces Nonapoptotic Cell Death in Leukemia Cells Independent of the 67 kDa Laminin Receptor (2011)

22. Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2 (2010)

23. The Green Tea Extract EGCG Demonstrates Synergist Activity against CLL B-Cells When Combined with Fludarabine and Chlorambucil. (2009)

24. Difference in Growth Suppression and Apoptosis Induction of EGCG and EGC on Human Promyelocytic Leukemia HL-60 Cells (2009)

25. Differentiation-associated alteration in sensitivity to apoptosis induced by (-)-Epigallocatechin-3-O-gallate in HL-60 cells (2009)

26. Catechin, green tea component, causes caspase independent necrosis-like cell death in chronic myelogenous leukemia (2009)

27. Epigallocatechin-3-gallate induces apoptosis and cell cycle arrest in HTLV-1-positive and -negative leukemia cells (2008)

28. (-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase (2008)

29. Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg (2007)

30. Increased radiation sensitivity of an eosinophilic cell line following treatment with epigallocatechin-gallate, resveratrol and curcuma (2005)

31. VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia (2004)

32. Gene expression spectra in human leukemia HL-60 cells treated with EGCG (2004)

33. Anti-proliferative and differentiation-inducing activities of the green tea catechin epigallocatechin-3-gallate (EGCG) on the human eosinophilic leukemia EoL-1 cell line (2002)

34. Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis (2001)

35. Green Tea Polyphenols Induce Apoptosis in vitro in Peripheral Blood T Lymphocytes of Adult T-Cell Leukemia Patients (2000)

In Vivo

1. (–)‑Epigallocatechin‑3‑gallate induces apoptosis and differentiation in leukaemia by targeting reactive oxygen species and PIN1 (2021)

2. A two-pronged anti-leukemic agent based on a hyaluronic acid–green tea catechin conjugate for inducing targeted cell death and terminal differentiation (2020)

3. Reactive oxygen species production triggers green tea-induced antileukaemic effects on acute promyelocytic leukaemia model (2018)

4. Epigallocatechin Gallate (EGCG), Influences a Murine WEHI-3 Leukemia Model In Vivo Through Enhancing Phagocytosis of Macrophages and Populations of T- and B-Cells (2013)

Clinical Trials

1. Immunomodulatory Effect of Green Tea Treatment in Combination with Low-dose Chemotherapy in Elderly Acute Myeloid Leukemia Patients with Myelodysplasia-related Changes (2021)

2. A Case of Complete and Durable Molecular Remission of Chronic Lymphocytic Leukemia Following Treatment with Epigallocatechin-3-gallate, an Extract of Green Tea (2015)

3. Phase 2 Trial of Daily, Oral Polyphenon E in Patients With Asymptomatic, Rai Stage 0 to II Chronic Lymphocytic Leukemia (2013)

4. REGULATORY T-CELL MODULATION BY GREEN TEA IN CHRONIC LYMPHOCYTIC LEUKEMIA (2013)

5. Phase I Trial of Daily Oral Polyphenon E in Patients With Asymptomatic Rai Stage 0 to II Chronic Lymphocytic Leukemia (2009)

6. Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies (2006)

Review

1. The Anti-Leukemic Activity of Natural Compounds (2021)

2. Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential (2021)

3. Evidence for and Against Green Tea and Turmeric in the Management of Chronic Lymphocytic Leukemia (2018)

4. The use of inexpensive broad spectrum lower toxicity therapeutics in chronic lymphocytic leukemia (2017)

5. Apoptosis inducers in chronic lymphocytic leukemia (2013)

6. Maintenance Therapy for B-Chronic Lymphocytic Leukemia (2011)

Liver Cancer

In Vitro

1. Epigallocatechin gallate-capped gold nanoparticles enhanced the tumor suppressors let-7a and miR-34a in hepatocellular carcinoma cells (2020)

2. RNA-seq data analysis of stimulated hepatocellular carcinoma cells treated with epigallocatechin gallate and fisetin reveals target genes and action mechanisms (2020)

3. Anti-proliferative and anti-apoptotic potential effects of epigallocatechin-3-gallate and/or metformin on hepatocellular carcinoma cells: in vitro study (2019)

4. Synergetic Effect of EP1 Receptor Antagonist and (-)-Epigallocatechin-3-gallate in Hepatocellular Carcinoma (2019)

5. Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells (2018)

6. A new molecular mechanism underlying the EGCG mediated autophagic modulation of AFP in HepG2 cells (2017)

7. Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation (2016)

8. Green tea component epigallocatechin-3-gallate decreases expression of osteopontin via a decrease in mRNA half-life in cell lines of metastatic hepatocellular carcinoma (2015)

9. Epigallocatechin 3 gallate induces the apoptosis of hepatocellular carcinoma LM6 cells but not non cancerous liver cells (2015)

10. Epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes S phase arrest in hepatocellular carcinoma by suppressing the AKT pathway (2014)

11. Curcumin and (-)-epigallocatechin-3-gallate attenuate acrylamide-induced proliferation in HepG2 cells (2014)

12. Epigallocatechin-3-Gallate Inhibits Hepatoblastoma Growth by Reactivating the Wnt Inhibitor SFRP1 (2013)

13. Anti-metastatic and differential effects on protein expression of epigallocatechin-3-gallate in HCCLM6 hepatocellular carcinoma cells (2013)

14. Prostanoid EP1 receptor as the target of (–)-epigallocatechin-3-gallate in suppressing hepatocellular carcinoma cells in vitro (2012)

15. Green tea polyphenol epigallocatechin-3-gallate enhances 5-fluorouracil-induced cell growth inhibition of hepatocellular carcinoma cells (2012)

16. Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells (2010)

17. Green tea polyphenol epigallocatechin-3-gallate inhibits thrombin-induced hepatocellular carcinoma cell invasion and p42/p44-MAPKinase activation (2009)

18. EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells (2009)

19. (-)-Epigallocatechin-3-gallate Induces Apoptosis of Human Hepatoma Cells by Mitochondrial Pathways Related to Reactive Oxygen Species (2009)

20. EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells (2008)

21. Impact of epigallocatechin gallate on gene expression profiles of human hepatocellular carcinoma cell lines BEL7404/ADM and BEL7402/5-FU (2008)

22. Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1A protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells (2006)

23. Inhibition of green tea catechins against the growth of cancerous human colon and hepatic epithelial cells (2001)

24. Suppression of adhesion and invasion of hepatoma cells in culture by tea compounds through antioxidative activity (2000)

In Vivo

1. Anti-angiogenic effect of the combination of low-dose sorafenib and EGCG in HCC-induced Wistar rats (2022)

2. Oral administration of EGCG solution equivalent to daily achievable dosages of regular tea drinkers effectively suppresses miR483-3p induced metastasis of hepatocellular carcinoma cells in mice (2021)

3. Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma (2020)

4. Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A (2020)

5. Chemoprevention of elite tea variety CFT‐1 rich in EGCG against chemically induced liver cancer in rats (2019)

6. ERα36 is an effective target of epigallocatechin-3-gallate in hepatocellular carcinoma (2019)

7. In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity(2016)

8. Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice (2016)

9. Tea polyphenols epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways (2015)

10. Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate (2015)

11. Chemopreventive and hepatoprotective effects of Epigallocatechin-gallate against hepatocellular carcinoma: role of heparan sulfate proteoglycans pathway (2014)

12. Autophagy Inhibition Contributes to the Synergistic Interaction between EGCG and Doxorubicin to Kill the Hepatoma Hep3B Cells (2014)

13. Effect of Tea Polyphenol on Oxidative Injury in S180 Cells Induced Hepatocarcinoma Mice (2012)

14. Preventive Effects of (-)-Epigallocatechin Gallate on Diethylnitrosamine-Induced Liver Tumorigenesis in Obese and Diabetic C57BL/KsJ-db/db Mice (2011)

15. Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer (2010)

16. Carbonyl Reductase 1 as a Novel Target of (2)-Epigallocatechin Gallate Against Hepatocellular Carcinoma (2010)

17. (–)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor–vascular endothelial growth factor receptor axis (2009)

18. A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins (2006)

Clinical Trials

1. Mitigation of Fumonisin Biomarkers by Green Tea Polyphenols in a High-Risk Population of Hepatocellular Carcinoma (2015)

2. Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population (2011)

3. Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine (2006)

Systematic Review, Meta-Analysis and Review

1. Coffee, Green Tea Intake, and the Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Observational Studies (2023)

2. The potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma (2023)

3. Tea Consumption and Risk of Cancer: An Umbrella Review and Meta-Analysis of Observational Studies (2020)

4. Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives (2019)

5. Green Tea Consumption: A Potential Chemopreventive Measure for Hepatocellular Carcinoma? (2018)

6. Chemopreventive Potential of Green Tea Catechins in Hepatocellular Carcinoma (2015)

Lung Cancer

In Vitro

1. Effect of Epigallocatechin-3-Gallate on EGFR Signaling and Migration in Non-Small Cell Lung Cancer (2021)

2. LC–MS Based Metabolomics Study of the Effects of EGCG on A549 Cells (2021)

3. Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMPactivated protein kinase signaling pathway (2020)

4. Next-Generation Sequencing Reveals the Role of Epigallocatechin-3-Gallate in Regulating Putative Novel and Known microRNAs Which Target the MAPK Pathway in Non-Small-Cell Lung Cancer A549 Cells (2019)

5. Epigallocatechin 3 gallate modulates long non coding RNA and mRNA expression profiles in lung cancer cells (2019)

6. Study of EGCG induced apoptosis in lung cancer cells by inhibiting PI3K/Akt signaling pathway (2018)

7. Differential proteomic analysis reveals that EGCG inhibits HDGF and activates apoptosis to increase the sensitivity of non-small cells lung cancer to chemotherapy (2016)

8. EGCG induces lung cancer A549 cell apoptosis by regulating Ku70 acetylation (2016)

9. Epigallocatechin-3-Gallate Enhances the Therapeutic Effects of Leptomycin B on Human Lung Cancer A549 Cells (2015)

10. Green tea catechin, epigallocatechin 3 gallate, attenuates the cell viability of human non small cell lung cancer A549 cells via reducing Bcl xL expression (2014)

11. Reversal of Cisplatin Resistance by Epigallocatechin Gallate Is Mediated by Downregulation of Axl and Tyro 3 Expression in Human Lung Cancer Cells (2014)

12. Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway (2014)

13. TGF-b1-induced epithelial–mesenchymal transition and acetylation of Smad2 and Smad3 are negatively regulated by EGCG in Human A549 lung cancer cells (2013)

14. Epigallocatechin gallate promotes p53 accumulation and activity via the inhibition of MDM2-mediated p53 ubiquitination in human lung cancer cells (2013)
15. EGCG Inhibits Transforming Growth Factor-β-Mediated Epithelial-to-Mesenchymal Transition via the Inhibition of Smad2 and Erk1/2 Signaling Pathways in Nonsmall Cell Lung Cancer Cells (2012)

16. Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1a (2011)

17. Epigallocatechin Gallate Suppresses Lung Cancer Cell Growth through Ras–GTPase-Activating Protein SH3 Domain-Binding Protein 1 (2010)

18. Identification of epigallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549 (2009)

19. Promoter Demethylation of WIF-1 by Epigallocatechin-3-gallate in Lung Cancer Cells (2009)

In Vivo

1. (−)-Epigallocatechin gallate inhibits stemness and tumourigenicity stimulated by AXL receptor tyrosine kinase in human lung cancer cells (2020)

2. EGCG regulates CTR1 expression through its pro‐oxidative property in non‐small‐cell lung cancer cells (2020)

3. Epigallocatechin‑3‑gallate inhibits self‑renewal ability of lung cancer stem‑like cells through inhibition of CLOCK (2020)

4. Epigallocatechin-3-gallate-induced vascular normalization in A549-cell xenograft-bearing nude mice: therapeutic efficacy in combination with chemotherapy (2019)

5. Synergistic inhibition of lung cancer cells by EGCG and NF-κB inhibitor BAY11-7082(2019)

6. Epigallocatechin‐3‐gallate inhibited cancer stem cell–like properties by targeting hsa‐mir‐485‐5p/RXRα in lung cancer (2018)

7. Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway(2017)

8. NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells (2016)

9. Epigallocatechin-3-gallate inhibits nicotine‑induced migration and invasion by the suppression of angiogenesis and epithelial‑mesenchymal transition in non-small cell lung cancer cells (2015)

10. Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer (2014)

11. EGCG Enhances the Efficacy of Cisplatin by Downregulating hsa-miR-98-5p in NSCLC A549 Cells (2014)

12. Effects of Epigallocatechin-3-gallate (EGCG) on A549 Lung Cancer Tumor Growth and Angiogenesis (2013)

13. Epigallocatechin-3-Gallate Inhibits IGF-I-Stimulated Lung Cancer Angiogenesis through Downregulation of HIF-1α and VEGF Expression (2013)

14. Tea polyphenols prevent lung from preneoplastic lesions and effect p53 and bcl-2 gene expression in rat lung tissues (2013)

15. Role of Ku70 and Bax in epigallocatechin-3-gallate inducedapoptosis of A549 cells in vivo (2013)

16. EGCG Inhibits the Invasion of Highly Invasive CL1-5 Lung Cancer Cells through Suppressing MMP-2 Expression via JNK Signaling and Induces G2/M Arrest (2011)

17. Pro-oxidative activities and dose–response relationship of (2)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro (2010)

18. The Green Tea Polyphenol EGCG Potentiates the Antiproliferative Activity of c-Met and Epidermal Growth Factor Receptor Inhibitors in Non–small Cell Lung Cancer Cells (2009)

Clinical Trials

1. A phase I study of concurrent chemotherapy and thoracic radiotherapy with oral epigallocatechin-3-gallate protection in patients with locally advanced stage III non-small-cell lung cancer (2014)

2. Phase I Trial of Oral Green Tea Extract in Adult Patients With Solid Tumors (2001)

Systematic Review and Review

1. Preventive and therapeutic effects of green tea on lung cancer: a narrative review of evidence from clinical and basic research (2022)

2. Green Tea and Lung Cancer: A Systematic Review (2013)

Lymphoma

1. Treatment of lymphomas via regulating the Signal transduction pathways by natural therapeutic approaches: A review (2021)

2. Epigallocatechin-3-gallate downregulates PDHA1 interfering the metabolic pathways in human herpesvirus 8 harboring primary effusion lymphoma cells (2020)

3. Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells (2018)

4. (-)-Epigallocatechingallate induces apoptosis in B lymphoma cells via caspase-dependent pathway and Bcl-2 family protein modulation (2015)

5. Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a (2013)

6. Inhibition of angiogenesis and induction of endothelial and tumor cell apoptosis by green tea in animal models of human high-grade non-Hodgkin’s lymphoma (2000)

Oral Cancer

In Vitro

1. Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase (2022)

2. Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway (2018)

3. Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells (2015)

4. Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2 (2012)

5. Synergistic Growth Inhibition of Squamous Cell Carcinoma of the Head and Neck by Erlotinib and Epigallocatechin-3-Gallate: The Role of p53-Dependent Inhibition of Nuclear Factor-κB (2009)

6. Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells (2008)

7. Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator (2007)

8. Role of p21WAF1 in Green Tea Polyphenol-induced Growth Arrest and Apoptosis of Oral Carcinoma Cells (2005)

9. In vitro Cytotoxicity of Epigallocatechin Gallate and Tea Extracts to Cancerous and Normal Cells from the Human Oral Cavity (2004)

10. Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction (2002)

11. Effects of Epigallocatechin-3-gallate on Growth, Epidermal Growth Factor Receptor Signaling Pathways, Gene Expression, and Chemosensitivity in Human Head and Neck Squamous Cell Carcinoma Cell Lines (2001)

In Vivo

1. EGCG inhibits growth of tumoral lesions on lip and tongue of K-Ras transgenic mice through the Notch pathway (2022)

2. CHEMOPREVENTIVE EFFECT OF GREEN TEA AND CURCUMIN IN INDUCED ORAL SQUAMOUS CELL CARCINOMA: AN EXPERIMENTAL STUDY (2020)

3. Epigallocatechin-3-gallate sensitises multidrug-resistant oral carcinoma xenografts to vincristine sulfate (2020)

4. Epigallocatechin-3 gallate inhibits cancer invasion by repressing functional invadopodia formation in oral squamous cell carcinoma (2013)

5. Epigallocatechin-3 Gallate Inhibits Invasion, Epithelial-Mesenchymal Transition, and Tumor Growth in Oral Cancer Cells (2011)

6. Green tea (−)-epigallocatechin-3-gallate inhibits HGF-induced progression in oral cavity cancer through suppression of HGF/c-Met (2011)

7. The repressive effect of green tea ingredients on amyloid precursor protein (APP) expression in oral carcinoma cells in vitro and in vivo (2007)

8. EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: Role of c-Jun N-terminal kinase (2007)

9. Therapeutic efficacy of green tea polyphenols on cellular thiols in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis (2004)

10. Inhibition of 7,12-dimethylbenz(α)anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin (2002)

Clinical Trials

1. Epigallocatechin-3-gallate mouthwash protects mucosa from radiation-induced mucositis in head and neck cancer patients: a prospective, non-randomised, phase 1 trial (2019)

2. Phase II Randomized, Placebo-controlled Trial of Green Tea Extract in Patients with High-risk Oral Premalignant Lesions (2009)

3. Oral Cancer Prevention Advances with a Translational Trial of Green Tea (2009)

4. Molecular and cellular effects of green tea on oral cells of smokers: A pilot study (2005)

Review

1. Chemoprevention of oral cancer: Green tea Experience (2014)

2. Chemopreventive Potential of Flavonoids in Oral Squamous Cell Carcinoma in Human Studies (2013)

3. Protection of Dietary Polyphenols against Oral Cancer (2013)

4. Green tea: A novel functional food for the oral health of older adults (2013)

5. The Chemopreventive Properties and Therapeutic Modulation of Green Tea Polyphenols in Oral Squamous Cell Carcinoma (2011)

6. Chemoprevention of Head and Neck Cancer with Green Tea Polyphenols (2010)

Ovarian Cancer

In Vitro

1. PTEN/AKT/mTOR signaling mediates anticancer effects of epigallocatechin‑3‑gallate in ovarian cancer (2020)

2. The modulatory effect of green tea catechin on drug resistance in human ovarian cancer cells (2019)

3. Green tea extract affects porcine ovarian cell apoptosis (2018)

4. Bioinformatics Analysis on Molecular Mechanism of Green Tea Compound Epigallocatechin-3-Gallate Against Ovarian Cancer (2017)

5. Tea polyphenol decreased growth and invasion in human ovarian cancer cells (2016)

6. Synergistic enhancement of anticancer effects on numerous human cancer cell lines treated with the combination of EGCG, other green tea catechins, and anticancer compounds (2014)

7. Epigallocatechin 3 gallate inhibits the proliferation and migration of human ovarian carcinoma cells by modulating p38 kinase and matrix metalloproteinase 2 (2014)

8. Epigallocatechin Gallate and Sulforaphane Combination Treatment Induce Apoptosis in Paclitaxel-Resistant Ovarian Cancer Cells through hTERT and Bcl-2 Down-regulation (2013)

9. Enhancement of Cisplatin-Mediated Apoptosis in Ovarian Cancer Cells through Potentiating G2/M Arrest and p21 Upregulation by Combinatorial Epigallocatechin Gallate and Sulforaphane (2013)

10. Epigallocatechin Gallate Acts Synergistically in Combination with Cisplatin and Designed trans-palladiums in Ovarian Cancer Cells (2012)

11. Inhibitory effect of Epigallocatechin gallate on ovarian cancer cell proliferation associated with aquaporin 5 expression (2012)

12. Synergism from Sequenced Combinations of Curcumin and Epigallocatechin-3-gallate with Cisplatin in the Killing of Human Ovarian Cancer Cells (2011)

13. Epigallocatechin-3-gallate, a Natural Polyphenol, Inhibits Cell Proliferation and Induces Apoptosis in Human Ovarian Cancer Cells (2010)

14. The Role of Green Tea Extract on the Poliferation of Human Ovarian Cancer Cell (in vitro) Study (2010)

15. Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma (2006)

16. Epigallocatechin-3-Gallate Delivers Hydrogen Peroxide to Induce Death of Ovarian Cancer Cells and Enhances Their Cisplatin Susceptibility (2006)

17. Anticancer effects of (-)-epigallocatechin-3-gallate on ovarian carcinoma cell lines (2004)

18. Activity of Green T ea Polyphenol Epigallocatechin-3-gallate Against Ovarian Carcinoma Cell Lines (2004)

In Vivo

1. The Potential Roles of Epigallocatechin-3-Gallate in the Treatment of Ovarian Cancer: Current State of Knowledge (2020)

2. Protective E_ects of Epigallocatechin Gallate (EGCG) on Endometrial, Breast, and Ovarian Cancers (2020)

3. EGCG Enhances Cisplatin Sensitivity by Regulating Expression of the Copper and Cisplatin Influx Transporter CTR1 in Ovary Cancer (2015)

Clinical Trials

1. Tea consumption and the risk of ovarian cancer: A meta-analysis of epidemiological studies (2017)

2. Green and black tea in relation to gynecologic cancers (2011)

3. GREEN TEA CONSUMPTION ENHANCES SURVIVAL OF EPITHELIAL OVARIAN CANCER (2004)

4. Tea Consumption and Ovarian Cancer Risk: A Case-Control Study in China (2002)

Pancreatic Cancer

In Vitro

1. Targeting a transcription factor NF-B by green tea catechins using in silico and in vitro studies in pancreatic cancer (2023)

2. The role of catechin in electroporation of pancreatic cancer cells – Effects on pore formation and multidrug resistance proteins (2022)

3. ( ) Epigallocatechin 3 gallate induces apoptosis in human pancreatic cancer cells via PTEN (2016)

4. Inhibitory effect of (−)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancer MiaPaca-2 cell growth (2015)

5. Inhibitory effects of (-)-epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitro (2012)

6. EGCG Enhances the Therapeutic Potential of Gemcitabine and CP690550 by Inhibiting STAT3 Signaling Pathway in Human Pancreatic Cancer (2012)

7. Inhibitory effects of epigallocatechin-3-gallate on cell proliferation and the expression of HIF-1α and P-gp in the human pancreatic carcinoma cell line PANC-1 (2012)

8. Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells (2011)

9. Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor (2010)

10. Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells (2005)

11. Suppression of Human Pancreatic Carcinoma Cell Growth and Invasion by Epigallocatechin-3-Gallate (2002)

In Vivo

1. Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine (2019)

2. PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma (2017)

3. EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin (2013)

Clinical Trial

1. Green tea drinking and risk of pancreatic cancer: A large-scale, population-based case–control study in urban Shanghai (2012)

Prostate Cancer

In Vitro

1. Development of (−)-epigallocatechin-3-gallateloaded folate receptor-targeted nanoparticles for prostate cancer treatment (2022)

2. Epigallocatechin-3-gallate mobilizes intracellular Ca2+ in prostate cancer cells through combined Ca2+ entry and Ca2+-induced Ca2+ release (2020)

3. Epigallocatechin-3-Gallate Suppresses Vasculogenic Mimicry through Inhibiting the Twist/VE-Cadherin/AKT Pathway in Human Prostate Cancer PC-3 Cells (2020)

4. Lipophilized Epigallocatechin Gallate Derivative Exerts Anti-Proliferation Efficacy through Induction of Cell Cycle Arrest and Apoptosis on DU145 Human Prostate Cancer Cells (2020)

5. Epigallocatechin-3-gallate Enhances the Efficacy of MicroRNA-34a Mimic and MicroRNA-93 Inhibitor Co-transfection in Prostate Cancer Cell Line (2020)

6. Green tea–induced epigenetic reactivation of tissue inhibitor of matrix metalloproteinase‐3 suppresses prostate cancer progression through histone‐modifying enzymes (2019)

7. EGCG/gelatin-doxorubicin gold nanoparticles enhance therapeutic efficacy of doxorubicin for prostate cancer treatment (2016)

8. Sensitization to docetaxel in prostate cancer cells by green tea and quercetin (2015)

9. Synergistic anticancer activity of biological from green and black tea on DU 145 human prostate cancer cells (2015)

10. The Polyphenols (2)-Epigallocatechin-3-Gallate and Luteolin Synergistically Inhibit TGF--Induced Myofibroblast Phenotypes through RhoA and ERK Inhibition (2014)

11. Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells (2014)

12. Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells (2013)

13. Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases (2012)

14. EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity (2012)

15. Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer (2011)

16. Green Tea Extract (Epigallocatechin-3-Gallate) Reduces Efficacy of Radiotherapy on Prostate Cancer Cells (2011)

17. Targeted Biocompatible Nanoparticles for the Delivery of (-)-Epigallocatechin 3-Gallate to Prostate Cancer Cells (2011)

18. Epigallocatechin gallate-loaded polysaccharide nanoparticles for prostate cancer chemoprevention (2011)

19. Therapeutic Effect of Epigallocatechin-3-gallate (EGCG) and Silibinin on ATM Dynamics in Prostate Cancer Cell Line LNCaP (2010)

20. The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition (2010)

21. Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells (2010)

22. The Polyphenol Epigallocatechin-3-Gallate Affects Lipid Rafts to Block Activation of the c-Met Receptor in Prostate Cancer Cells (2010)

23. Targeting CWR22Rv1 Prostate Cancer Cell Proliferation and Gene Expression by Combinations of the Phytochemicals EGCG, Genistein and Quercetin (2009)

24. Tea Polyphenols Decrease Serum Levels of Prostate-Specific Antigen, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor in Prostate Cancer Patients and Inhibit Production of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor In vitro (2009)

25. Dihydrotestosterone Sensitises LNCaP Cells to Death Induced by Epigallocatechin-3-Gallate (EGCG) or an IGF-I Receptor Inhibitor (2009)

26. Epigallocatechin-3-gallate affects the growth of LNCaP cells via membrane fluidity and distribution of cellular zinc (2009)

27. Mechanism of Free Zn(2+) Enhancing Inhibitory Effects of EGCG on the Growth of PC-3 Cells: Interactions with Mitochondria (2009)

28. Epigallocatechin-3-gallate (EGCG) inhibits PC-3 prostate cancer cell proliferation via MEK-independent ERK1/2 activation (2008)

29. Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis (2008)

30. Protein Phosphatase 1 Activation and Alternative Splicing of Bcl-X and Mcl-1 by EGCG + Ibuprofen (2008)

31. Investigations of the cytotoxicity of epigallocatechin-3-gallate against PC-3 cells in the presence of Cd2+ in vitro (2008)

32. Free Zn2+ enhances inhibitory effects of EGCG on the growth of PC-3 cells (2008)

33. Synergistic Cell Death by EGCG and Ibuprofen in DU-145 Prostate Cancer Cell Line (2007)

34. Epigallocatechin-3-gallate and bicalutamide cause growth arrest and apoptosis in NRP-152 and NRP-154 prostate epithelial cells (2007)

35. Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells (2007)

36. Effects of interactions of EGCG and Cd2+ on the growth of PC-3 cells and their mechanisms (2007)

37. Epigallocatechin gallate inhibits HIF-1a degradation in prostate cancer cells (2005)

38. Ablation of either p21 or Bax prevents p53-dependent apoptosis induced by green tea polyphenol epigallocatechin-3-gallate (2005)

39. Cytotoxicity of epigallocatechin-3-gallate to LNCaP cells in the presence of Cu2+ (2005)

40. Treatment of Epigallocatechin-3-Gallate Inhibits MatrixMetalloproteinases-2 and -9 via Inhibition of Activation of Mitogen-Activated Protein Kinases, c-jun and NF-B in Human Prostate Carcinoma DU-145 Cells (2004)

41. Modulation of Phosphatidylinositol-3-Kinase/Protein Kinase B- and Mitogen-Activated Protein Kinase-Pathways by Tea Polyphenols in Human Prostate Cancer Cells (2004)

42. PROSTATE CARCINOMA AND GREEN TEA: PSA-TRIGGERED BASEMENT MEMBRANE DEGRADATION AND MMP-2 ACTIVATION ARE INHIBITED BY (-)EPIGALLOCATECHIN-3-GALLATE (2004)

43. Role of p53 and NF-B in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells (2003)

44. Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells (2003)

45. EPIGALLOCATECHIN-3-GALLATE IS A POTENT NATURAL INHIBITOR OF FATTY ACID SYNTHASE IN INTACT CELLS AND SELECTIVELY INDUCES APOPTOSIS IN PROSTATE CANCER CELLS (2003)

46. Gene expression profile in human prostate LNCaP cancer cells by (2) epigallocatechin-3-gallate (2002)

47. Detrimental Effect of Cancer Preventive Phytochemicals Silymarin, Genistein and Epigallocatechin 3-gallate on Epigenetic Events in Human ProstateCarcinomaDU145Cells (2001)

48. Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells (2001)

49. Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells (2000)

50. Growth Inhibition, Cell-Cycle Dysregulation, and Induction of Apoptosis by Green Tea Constituent (-)-Epigallocatechin-3-gallate in Androgen-Sensitive and Androgen-Insensitive Human Prostate Carcinoma Cells (2000)

In Vivo

1. Targeted nanoparticles encapsulating (−)-epigallocatechin-3-gallate for prostate cancer prevention and therapy (2017)

2. Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy (2016)

3. The Heat Shock Protein 90 Inhibitor, (_)-Epigallocatechin Gallate, Has Anticancer Activity in a Novel Human Prostate Cancer Progression Model (2015)

4. Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model(2014)

5. Synergistic Effects of the Green Tea Extract Epigallocatechin-3-gallate and Taxane in Eradication of Maglinant Human Prostate Tumors (2011)

6. Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells(2010)

7. Combination Therapy with Epigallocatechin-3-Gallate and Doxorubicin in Human Prostate Tumor Modeling Studies (2010)

8. Common Botanical Compounds Inhibit the Hedgehog Signaling Pathway in Prostate Cancer (2010)

9. Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells (2009)

10. Combined Inhibitory Effects of GreenTea Polyphenols and Selective Cyclooxygenase-2 Inhibitors on the Growth of Human Prostate Cancer Cells Both In vitro and In vivo (2007)

11. Epigallocatechin-3-GallateSuppressesEarlyStage,but not Late Stage Prostate Cancer in TRAMP Mice: Mechanisms of Action (2007)

Clinical Trials

1. ProDiet: A Phase II Randomized Placebo controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer (2018)

2. Reduced prostate cancer risk with green tea and epigallocatechin 3-gallate intake among Hong Kong Chinese men (2017)

3. Randomized Clinical Trial of Brewed Green and Black Tea in Men With Prostate Cancer Prior to Prostatectomy (2015)

4. Randomized, Double-Blind, Placebo-Controlled Trial of Polyphenon E in Prostate Cancer Patients before Prostatectomy: Evaluation of Potential Chemopreventive Activities (2012)

5. Green Tea Polyphenols and Metabolites in Prostatectomy Tissue: Implications for Cancer Prevention (2010)

6. Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-Grade Prostate Intraepithelial Neoplasia: A Preliminary Report from a One-Year Proof-of-Principle Study (2006)

7. A Phase II Trial of Green Tea in the Treatment of Patients with Androgen Independent Metastatic Prostate Carcinoma (2003)

Review

1. Effects of Green Tea Catechins on Prostate Cancer Chemoprevention: The Role of the Gut Microbiome (2022)

2. Green Tea Epigallocatechin-3-Gallate Regulates Autophagy in Male and Female Reproductive Cancer (2022)

3. Anti-Cancer Effects of Green Tea Polyphenols Against Prostate Cancer (2019)

4. Green tea extract for prevention of prostate cancer progression in patients on active surveillance (2018)

5. Protective Effect of Green Tea (Camellia sinensis (L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients (2017)

6. Green Tea Polyphenols and Cancer Chemoprevention of Genitourinary Cancer(2013)

7. The epigenetic potentials of dietary polyphenols in prostate cancer Management (2013)

8. Modulation of signaling pathways in prostate cancer by green tea polyphenols (2012)

9. Chemopreventive effects of tea in prostate cancer: Green tea versus black tea (2011)

10. Green tea polyphenols for prostate cancer chemoprevention: A translational perspective (2010)

11. Review: Green Tea Polyphenols in Chemoprevention of Prostate Cancer: Preclinical and Clinical Studies (2009)

12. Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer (2006)

13. Molecular Targets for Green Tea in Prostate Cancer Prevention (2003)

Renal Cell Carcinoma

1. Green tea and coffee consumption and risk of kidney cancer in Japanese adults (2022)

2. Identification of EZH2 as Cancer Stem Cell Marker in Clear Cell Renal Cell Carcinoma and the Anti-Tumor Effect of Epigallocatechin-3-Gallate (EGCG) (2022)

3. The Role of Compounds Derived from Natural Supplement as Anticancer Agents in Renal Cell Carcinoma: A Review (2018)

4. Epigallocatechin 3 gallate inhibits migration and invasion of human renal carcinoma cells by downregulating matrix metalloproteinase 2 and matrix metalloproteinase 9 (2016)

5. Epigallocatechin-3-gallate Sensitizes Human 786-O Renal Cell Carcinoma Cells to TRAIL-Induced Apoptosis (2014)

6. Induction of the Connexin 32 Gene by Epigallocatechin-3-Gallate Potentiates Vinblastine-Induced Cytotoxicity in Human Renal Carcinoma Cells (2013)

7. Green tea: A promising anticancer agent for renal cell carcinoma (2010)

8. EGCG inhibits growth and induces apoptosis in renal cell carcinoma through TFPI-2 overexpression (2009)

9. Anticancer effect of lysine, proline, arginine, ascorbic acid and green tea extract on human renal adenocarcinoma line 786-0 (2006)

10. The Preventive Effect of Green Tea on the Gap Junction Intercellular Communication in Renal Epithelial Cells Treated with a Renal Carcinogen (2004)

Sarcoma

Bone

1. EGCG regulated osteolytic microenvironment to enhance the antitumor effect of DOX on orthotopic osteosarcoma (2022)

2. Epigallocatechin-3-gallate suppresses the growth of human osteosarcoma by inhibiting the Wnt/β- catenin signalling pathway (2022)

3. SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition (2018)

4. Epigallocatechin-3-gallate attenuates bone cancer pain involving decreasing spinal Tumor Necrosis Factor-α expression in a mouse model (2015)

5. Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1 (2015)

6. Overexpression of miR-126 sensitizes osteosarcoma cells to apoptosis induced by epigallocatechin-3-gallate (2014)

7. Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells (2012)

8. Inhibition of the Insulin-Like Growth Factor I Receptor by Epigallocatechin Gallate Blocks Proliferation and Induces the Death of Ewing Tumor Cells (2010)

9. Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-κB (2006)

Soft tissues

1. Modulation of cisplatin cytotoxic activity against leiomyosarcoma cells by epigallocatechin-3-gallate (2017)

2. Anti proliferative activity of epigallocatechin 3 gallate and silibinin on soft tissue sarcoma cells (2017)

3. (−)-Epigallocatechin-3-gallate alleviates doxorubicin-induced cardiotoxicity in sarcoma 180 tumor-bearing mice (2017)

4. Epigallocatechin-3-Gallate Induces Cell Apoptosis of Human Chondrosarcoma Cells Through Apoptosis Signal-Regulating Kinase 1 Pathway (2011)

5. (-)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells (2010)

6. Epigallocatechin gallate induced apoptosis in Sarcoma180 cells in vivo: Mediated by p53 pathway and inhibition in U1B, U4-U6 UsnRNAs expression (2006)

7. Regulation of urokinase plasminogen activator by epigallocatechin-3-gallate in human fibrosarcoma cells (2004)

8. Association of Suppression of Extracellular Signal-Regulated Kinase Phosphorylation by Epigallocatechin Gallate with the Reduction of Matrix Metalloproteinase Activities in Human Fibrosarcoma HT1080 Cells (2003)

9. Involvement of Caspase-3 in Epigallocatechin-3-gallate-Mediated Apoptosis of Human Chondrosarcoma Cells (2000)

Skin Cancer

In Vitro

1. EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells (2022)

2. Potential effect of EGCG on the anti-tumor efficacy of metformin in melanoma cells (2021)

3. Anti-melanogenic effects of epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG) and gallocatechin-3-gallate (GCG) via down-regulation of cAMP/CREB /MITF signaling pathway in B16F10 melanoma cells (2020)

4. Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa laminin receptor signaling in melanoma cells (2016)

5. The Bmi-1 helix–turn and ring finger domains are required for Bmi-1 antagonism of (−) epigallocatechin-3-gallate suppression of skin cancer cell survival (2015)

6. Green tea polyphenol, (−)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting β-catenin signaling (2013)

7. Higher cell stiffness indicating lower metastatic potential in B16 melanoma cell variants and in (-)-epigallocatechin gallate-treated cells (2012)

8. (-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells (2011)

9. (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells (2011)

10. Anti-Melanoma Effects of Vorinostat in Combination with Polyphenolic Antioxidant (−)-Epigallocatechin-3-Gallate (EGCG) (2010)

11. The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival (2010)

12. Differential Growth Suppression of Human Melanoma Cells by Tea (Camellia sinensis) Epicatechins (ECG, EGC and EGCG) (2009)

13. EGCG Enhances TRAIL-mediated Apoptosis in Human Melanoma A375 Cell Line (2009)

14. Inhibition of Invasion and Up-regulation of E-cadherin Expression in Human Malignant Melanoma Cell Line A375 by (-)-Epigallocatechin-3-gallate (2008)

15. Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: Possible implications for the chemoprevention of melanoma (2005)

16. (-)-Epigallocatechin-3-Gallate, a Polyphenolic Compound From Green Tea, Inhibits Fibroblast Adhesion and Migration Through Multiple Mechanisms (2005)

17. Inhibition of ultraviolet B-mediated activation of nuclear factor B in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate (2003)

18. THE GREEN TEA POLYPHENOL, EPIGALLOCATECHIN-3-GALLATE, PROTECTS AGAINST THE OXIDATIVE CELLULAR AND GENOTOXIC DAMAGE OF UVA RADIATION (2002)

19. Inhibitory effect of epigallocatechin gallate on adhesion of murine melanoma cells to laminin (2001)

20. Differential Responses of Skin Cancer-Chemopreventive Agents Silibinin, Quercetin, and Epigallocatechin 3-Gallate on Mitogenic Signaling and Cell Cycle Regulators in Human Epidermoid Carcinoma A431 Cells (2001)

In Vivo

1. EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses (2021)

2. Targeted Therapy against Metastatic Melanoma Based on Self-Assembled Metal-Phenolic Nanocomplexes Comprised of Green Tea Catechin (2019)

3. (-)-Epigallocatechin gallate (EGCG)-nanoethosomes as a transdermal delivery system for docetaxel to treat implanted human melanoma cell tumors in mice (2016)

4. Epigallocatechin-3-gallate (EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity (2016)

5. Excellent anti-proliferative and pro-apoptotic effects of (−)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo (2014)

6. Improving anticancer efficacy of (-)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanoma cells (2014)

7. Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1 secretion (2011)

8. (-)-Epigallocatechin-3-gallate (EGCG) sensitizes melanoma cells to interferon induced growth inhibition in a mouse model of human melanoma (2009)

9. Prevention of Ultraviolet Radiation-Induced Immunosuppression by (-)-Epigallocatechin-3-Gallate in Mice Is Mediated through Interleukin 12-Dependent DNA Repair (2006)

10. Effect of liposome encapsulation of tea catechins on their accumulation in basal cell carcinomas (2006)

11. Exceptionally High Protection of Photocarcinogenesis by Topical Application of (-)-Epigallocatechin-3-Gallate in Hydrophilic Cream in SKH-1 Hairless Mouse Model: Relationship to Inhibition of UVB-Induced Global DNA Hypomethylation (2003)

12. Inhibition of Melanoma Growth and Metastasis by Combination With (-)-Epigallocatechin-3-Gallate and Dacarbazine in Mice (2001)

Review

1. Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair (2007)

Stomach Cancer

In Vitro

1. Epigallocatechin Gallate Enhances Inhibition Effect of DDP on the Proliferation of Gastric Cancer BGC-823 Cells by Regulating p19Arf-p53-p21Cip1 Signaling Pathway (2021)

2. Epigallocatechin gallate reverses gastric cancer by regulating the long noncoding RNA LINC00511/miR-29b/KDM2A axis (2020)

3. Effects of EGCG on proliferation and apoptosis of gastric cancer SGC7901 cells via down-regulation of HIF-1α and VEGF under a hypoxic state (2019)

4. Cytotoxic Activity of Epigallocatechin and Trans- Cinnamaldehyde in Gastric Cancer Cell Line (2019)

5. Green tea polyphenols affect invasiveness of human gastric MKN-28 cells by inhibition of LPS or TNF-a induced Matrix Metalloproteinase-9/2 (2016)

6. Green Tea Extract Induces Apoptosis in the AGS Gastric Carcinoma Cell Line (2014)

7. Regulation of Id1 expression by epigallocatechin 3 gallate and its effect on the proliferation and apoptosis of poorly differentiated AGS gastric cancer cells (2013)

8. (−)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68 (2011)

9. (-)-Epigallocatechin-3-gallate induces apoptosis in gastric cancer cell lines by down-regulating survivin expression (2011)

10. Apoptotic effect of Epigallocatechin-3-gallate on the human gastric cancer cell line MKN45 via activation of the mitochondrial pathway (2007)

11. Synergistic Effect of Green Tea Catechins on Cell Growth and Apoptosis Induction in Gastric Carcinoma Cells (2005)

12. EGCG Blocks Tumor Promoter-induced MMP-9 Expression Via Suppression of MAPK and AP-1 Activation in Human Gastric AGS Cells (2004)

13. Activity-Guided Fractionation of Green Tea Extract with Antiproliferative Activity against Human Stomach Cancer Cells (2002)

In Vivo

1. Epigallocatechin Gallate Protects against MNNG-Induced Precancerous Lesions of Gastric Carcinoma in Rats via PI3K/Akt/mTOR Pathway (2021)

2. Reversal of 5-fluorouracil resistance by EGCG is mediate by inactivation of TFAP2A/VEGF signaling pathway and down-regulation of MDR-1 and P-gp expression in gastric cancer (2017)

3. Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice (2016)

4. EGCG Suppresses ERK5 Activation to Reverse Tobacco Smoke-Triggered Gastric Epithelial-Mesenchymal Transition in BALB/c Mice (2016)

5. Inhibition of green tea polyphenol EGCG ((−)-epigallocatechin-3-gallate) on the proliferation of gastric cancer cells by suppressing canonical wnt/β-catenin signalling pathway(2016)

6. EGCG inhibits recepteur d’origine nantais expression by suppressing Egr-1 in gastric cancer cells (2013)

7. Capecitabine combined with (-)-epigallocatechin-3-gallate inhibits angiogenesis and tumor growth in nude mice with gastric cancer xenografts (2012)

8. Low-Dose Docetaxel Combined with ( – )-Epigallocatechin-3-Gallate Inhibits Angiogenesis and Tumor Growth in Nude Mice with Gastric Cancer Xenografts (2012)

9. (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer (2011)

10. Green Tea Polyphenols Reduce Gastric Epithelial Cell Proliferation and Apoptosis Stimulated by Helicobacter pylori Infection (2007)

11. (-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis (2007)

Clinical Trials

1. Association of Risk of Gastric Cancer and Consumption of Tobacco, Alcohol and Tea in the Chinese Population (2014)

2. Green tea drinking and multigenetic index on the risk of stomach cancer in a Chinese population (2005)

3. Tea and coffee consumption and the risk of digestive tract cancers: data from a comparative case-referent study in Japan (1998)

4. Green-Tea Consumption and Risk of Stomach Cancer: A Population-Based Case-Control Study in Shanghai (1995)

Meta-analysis & Review

1. Tea Polyphenols and Their Preventive Measures against Cancer: Current Trends and Directions (2022)

2. Advances in the Antagonism of Epigallocatechin-3-gallate in the Treatment of Digestive Tract Tumors (2019)

3. Green Tea Consumption and Stomach Cancer Risk: A Meta-Analysis (2010)

Thyroid Cancer

1. Autophagy inhibition contributes to epigallocatechin‑3‑gallate‑mediated apoptosis in papillary thyroid cancer cells (2021)

2. Herbal Active Ingredients: An Emerging Potential for the Prevention and Treatment of Papillary Thyroid Carcinoma (2020)

3. Epigallocatechin gallate (EGCG) suppresses epithelial-Mesenchymal transition (EMT) and invasion in anaplastic thyroid carcinoma cells through blocking of TGF-β1/Smad signaling pathways (2019)

4. Epigallocatechin‑3‑gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway (2019)

5. Quantification of (-) Epigallocatechin‑3‑gallate Inhibition of Aplastic Thyroid Cancer Cell Line Adhesion and Proliferation Using Real-time Cell Analysis (2016)

6. Chemopreventive role of green tea in head and neck cancers (2014)

7. Green tea and coffee consumption and its association with thyroid cancer risk: a population-based cohort study in Japan (2011)

8. Epigallocatechin-3-gallate Induces Growth Inhibition and Apoptosis of Human Anaplastic Thyroid Carcinoma Cells Through Suppression of EGFR/ERK Pathway and Cyclin B1/CDK1 Complex (2011)

Uterine Cancer

1. Green Tea in Reproductive Cancers: Could Treatment Be as Simple? (2023)

2. Antioxidative, Anti-Inflammatory, Anti-Obesogenic, and Antidiabetic Properties of Tea Polyphenols—The Positive Impact of Regular Tea Consumption as an Element of Prophylaxis and Pharmacotherapy Support in Endometrial Cancer (2022)

3. Protective E_ects of Epigallocatechin Gallate (EGCG) on Endometrial, Breast, and Ovarian Cancers (2020)

4. Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer (2020)

5. Green tea, black tea consumption and risk of endometrial cancer: a systematic review and meta-analysis (2015)

6. Epigallocatechin-3-gallate potentiates curcumin’s ability to suppress uterine leiomyosarcoma cell growth and induce apoptosis (2013)

7. (−)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation (2013)

8. Antiproliferative and apoptotic effect of epigallocatechin- 3-gallate on Ishikawa cells is accompanied by sex steroid receptor downregulation (2012)

9. Green and black tea in relation to gynecologic cancers (2011)

10. Regulation of Vascular Endothelial Growth Factor in endometrial tumour cells by resveratrol and EGCG (2009)

11. Case–control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma (2009)

12. Interaction of Soy Food and Tea Consumption with CYP19A1 Genetic Polymorphisms in the Development of Endometrial Cancer (2007)