Apigenin

General Anti-cancer Activities

Breast Cancer

In Vitro

1. Apigenin, a Partial Antagonist of the Estrogen Receptor (ER), Inhibits ER-Positive Breast Cancer Cell Proliferation through Akt/FOXM1 Signaling (2021)

2. Effect of apigenin on whole transcriptome profile of TNFα‑activated MDA‑MB‑468 triple negative breast cancer cells (2020)

3. Whole Transcriptomic Analysis of Apigenin on TNFα Immuno-activated MDA-MB-231 Breast Cancer Cells (2019)

4. Anti-cancer Effect of Apigenin on Human Breast Carcinoma MDA-MB-231 through Cell Cycle Arrest and Apoptosis (2019)

5. Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro (2018)

6. Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells (2018)

7. Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity (2018)

8. Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells (2017)

9. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells (2017)

10. Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells (2017)

11. Apigenin Inhibits Growth of Breast Cancer Cells: The Role of ERα and HER2/neu (2015)

12. Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells (2015)

13. Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells (2015)

14. Induction of Caspase-dependent Apoptosis by Apigenin by Inhibiting STAT3 Signaling in HER2-overexpressing MDA-MB-453 Breast Cancer Cells (2014)

15. Apigenin Induced MCF-7 Cell Apoptosis-Associated Reactive Oxygen Species (2014)

16. Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells (2013)

17. Apigenin causes G2/M arrest associated with the modulation of p21Cip1 and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells (2009)

18. Apigenin Induces Apoptosis through a Mitrochondria/Caspase- Pathway in Human Breast Cancer MDA-MB-453 Cells (2009)

19. Apigenin Inhibits Antiestrogen-resistant Breast Cancer Cell Growth through Estrogen Receptor-α-dependent and -independent Mechanisms (2008)

20. Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neu in HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway (2004)

In Vivo

1. Apigenin by targeting hnRNPA2 sensitizes triple-negative breast cancer spheroids to doxorubicin-induced apoptosis and regulates expression of ABCC4 and ABCG2 drug efflux transporters (2020)

2. Antitumor and Anti-Invasive Effect of Apigenin on Human Breast Carcinoma through Suppression of IL-6 Expression (2019)

3. Inhibition of MDA-MB-231 Breast Cancer Cell Proliferation and Tumor Growth by Apigenin Through Induction of G2/M Arrest and Histone H3 Acetylation-mediated p21WAF1/CIP1 Expression (2016)

4. Apigenin Induces Apoptosis and Blocks Growth of Medroxyprogesterone Acetate-Dependent BT-474 Xenograft Tumors (2012)

Cervical Cancer

1. Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines

2. Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma

Colorectal Cancer

1. Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells

2. Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells

Liver Cancer

In Vitro

1. Investigation of possible effects of apigenin, sorafenib and combined applications on apoptosis and cell cycle in hepatocellular cancer cells (2020)

2. Apigenin and hesperidin augment the toxic effect of doxorubicin against HepG2 cells (2019)

3. Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway (2017)

4. Apigenin Sensitizes Huh-7 Human Hepatocellular Carcinoma Cells to TRAIL-induced Apoptosis (2012)

5. A mechanism of apigenin-induced apoptosis is potentially related to anti-angiogenesis and anti-migration in human hepatocellular carcinoma cells (2011)

In Vivo

1. Apigenin Inhibits the Growth of Hepatocellular Carcinoma Cells by Affecting the Expression of microRNA Transcriptome (2021)

2. Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways (2021)

3. H19-Wnt/β-catenin regulatory axis mediates the suppressive effects of apigenin on tumor growth in hepatocellular carcinoma (2021)

4. Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells (2018)

5. Apigenin inhibits NF-κB and Snail signaling, EMT and metastasis in human hepatocellular carcinoma (2016)

6. Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway (2013)

7. Apigenin inhibits hepatoma cell growth through alteration of gene expression patterns (2011)

Lung Cancer

1. Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependentmanner

2. Apigenin induces caspase-dependent apoptosis inhuman lung cancer A549 cells through Bax- andBcl-2-triggered mitochondrial pathway

3. Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer

Ovarian Cancer

1. Oral Administration of Apigenin Inhibits Metastasis through AKT/P70S6K1 /MMP-9 Pathway in Orthotopic Ovarian Tumor Model

2. Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1