Sarcoma

Bone

Curcumin

1. Curcumin Induces Cell Cycle Arrest and Apoptosis in Human Osteosarcoma (HOS) Cells

2. Apoptotic effects of curcumin on human osteosarcomaU2OS cells

GreenTea

1. EGCG regulated osteolytic microenvironment to enhance the antitumor effect of DOX on orthotopic osteosarcoma (2022)

2. Epigallocatechin-3-gallate suppresses the growth of human osteosarcoma by inhibiting the Wnt/β- catenin signalling pathway (2022)

3. SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition (2018)

4. Epigallocatechin-3-gallate attenuates bone cancer pain involving decreasing spinal Tumor Necrosis Factor-α expression in a mouse model (2015)

5. Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1 (2015)

6. Overexpression of miR-126 sensitizes osteosarcoma cells to apoptosis induced by epigallocatechin-3-gallate (2014)

7. Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells (2012)

8. Inhibition of the Insulin-Like Growth Factor I Receptor by Epigallocatechin Gallate Blocks Proliferation and Induces the Death of Ewing Tumor Cells (2010)

9. Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-κB (2006)

Luteolin

1. The flavonoid luteolin enhances doxorubicin-induced autophagy in human osteosarcoma U2OS cells

2. Molecular Mechanisms of Luteolin Induced Growth Inhibition and Apoptosis of Human Osteosarcoma Cells

Panax ginseng

1. GinsenosideRg3 Suppresses Proliferation and Induces Apoptosis in Human Osteosarcoma

2. Ginseng polysaccharide serves as a potential radiosensitizer through inducing apoptosis and autophagy in the treatment of osteosarcoma

3. GinsenosideRg3 induces DNA damage in human osteosarcoma cells and reduces MNNG-induced DNA damage and apoptosis in normal human cells

Quercetin

1. Quercetin Inhibits Cell Migration and Invasion in Human Osteosarcoma Cells

2. Autophagy Inhibition Promotes Quercetin Induced Apoptosis in MG-63 Human Osteosarcoma cells

3. Evaluation of Quercetin as a Potential Drug in Osteosarcoma Treatment

Resveratrol

1. Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma Cells

2. Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

Silymarin

1. Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2

Vitamin C

1. The effect of ascorbic acid on bone cancer cells in vitro

Soft Tissue

Green Tea

1. Modulation of cisplatin cytotoxic activity against leiomyosarcoma cells by epigallocatechin-3-gallate (2017)

2. Anti proliferative activity of epigallocatechin 3 gallate and silibinin on soft tissue sarcoma cells (2017)

3. (−)-Epigallocatechin-3-gallate alleviates doxorubicin-induced cardiotoxicity in sarcoma 180 tumor-bearing mice (2017)

4. Epigallocatechin-3-Gallate Induces Cell Apoptosis of Human Chondrosarcoma Cells Through Apoptosis Signal-Regulating Kinase 1 Pathway (2011)

5. (-)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells (2010)

6. Epigallocatechin gallate induced apoptosis in Sarcoma180 cells in vivo: Mediated by p53 pathway and inhibition in U1B, U4-U6 UsnRNAs expression (2006)

7. Regulation of urokinase plasminogen activator by epigallocatechin-3-gallate in human fibrosarcoma cells (2004)

8. Association of Suppression of Extracellular Signal-Regulated Kinase Phosphorylation by Epigallocatechin Gallate with the Reduction of Matrix Metalloproteinase Activities in Human Fibrosarcoma HT1080 Cells (2003)

9. Involvement of Caspase-3 in Epigallocatechin-3-gallate-Mediated Apoptosis of Human Chondrosarcoma Cells (2000)

Resveratrol

1. Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity

2. Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3 kinase/AKT and p38 mitogen-activated protein kinase pathways